Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Okba, Nisreen M.A. ; Widjaja, Ivy ; Li, Wentao ; GeurtsvanKessel, Corine H. ; Farag, Elmoubasher A.B.A. ; Al-Hajri, Mohammed ; Park, Wan Beom ; Oh, Myoung-don ; Reusken, Chantal B.E.M. ; Koopmans, Marion P.G. ; Bosch, Berend-Jan ; Haagmans, Bart L.
• Description:
  We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
• Subjects:
  Antibodies, Viral Coronavirus Infections Enzyme-Linked Immunosorbent Assay Humans Immunoassay Middle East Respiratory Syndrome Coronavirus Serologic Tests Species Specificity
• Source:
  Emerg Infect Dis. 26(5):1024-1027
• Pubmed ID:
  32150528
• Pubmed Central ID:
  PMC7181916
• Document Type:
  Letter
• Volume:
  26
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f7c1a1eae4894f6ad8ca1f8156d96183f725936e853ddbece8e54b3f216471a0
• Download URL:
  https://stacks.cdc.gov/view/cdc/87657/cdc_87657_DS1.pdf
• File Type:
  [PDF - 1.34 MB ]