Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Okba, Nisreen M.A.; Widjaja, Ivy; Li, Wentao; GeurtsvanKessel, Corine H.; Farag, Elmoubasher A.B.A.; Al-Hajri, Mohammed; Park, Wan Beom; Oh, Myoung-don; Reusken, Chantal B.E.M.; Koopmans, Marion P.G.; Bosch, Berend-Jan; Haagmans, Bart L.

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

May 17 2020
By Okba, Nisreen M.A. ; Widjaja, Ivy ; Li, Wentao ; ...
Source: Emerg Infect Dis. 26(5):1024-1027

[PDF-1.34 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Okba, Nisreen M.A. ; Widjaja, Ivy ; Li, Wentao ; GeurtsvanKessel, Corine H. ; Farag, Elmoubasher A.B.A. ; ... More +

Okba, Nisreen M.A. ; Widjaja, Ivy ; Li, Wentao ; GeurtsvanKessel, Corine H. ; Farag, Elmoubasher A.B.A. ; Al-Hajri, Mohammed ; Park, Wan Beom ; Oh, Myoung-don ; Reusken, Chantal B.E.M. ; Koopmans, Marion P.G. ; Bosch, Berend-Jan ; Haagmans, Bart L. Less -
Description:

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
Subjects:

[+]

Antibodies, Viral Coronavirus Infections Enzyme-Linked Immunosorbent Assay Humans Immunoassay Middle East Respiratory Syndrome Coronavirus Serologic Tests Species Specificity
Source:

Emerg Infect Dis. 26(5):1024-1027
Pubmed ID:

32150528
Pubmed Central ID:

PMC7181916
Document Type:

Letter
Volume:

26
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:f7c1a1eae4894f6ad8ca1f8156d96183f725936e853ddbece8e54b3f216471a0
Download URL:

https://stacks.cdc.gov/view/cdc/87657/cdc_87657_DS1.pdf
File Type:

	19-0921-F.gif	gif
	19-0921-F.jpg	jpeg
	19-0921-Techapp-s1.pdf	pdf
	19-0921.nxml	xml

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