Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Wu, Chi-Jung ; Liu, Wei-Lun ; Lai, Chih-Cheng ; Chao, Chien-Ming ; Ko, Wen-Chien ; Wang, Hsuan-Chen ; Dai, Ching-Tzu ; Hsieh, Ming-I ; Choi, Pui-Ching ; Yang, Jia-Ling ; Chen, Yee-Chun
• Description:
  In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR|/L98H, TR|/L98H/S297T/F495I, and TR|/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.
• Subjects:
  Antifungal Agents Aspergillus Fumigatus Azoles Drug Resistance, Fungal Fungal Proteins Microbial Sensitivity Tests
• Source:
  Emerg Infect Dis. 26(4):806-809
• Pubmed ID:
  32186508
• Pubmed Central ID:
  PMC7101115
• Document Type:
  Journal Article
• Genre:
  Letter
• Place as Subject:
  Taiwan
• Volume:
  26
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f09c7af0c2630e988268b52435a6a4baaad931a3db4491f6f9e5248b81769aa1
• Download URL:
  https://stacks.cdc.gov/view/cdc/86475/cdc_86475_DS1.pdf
• File Type:
  [PDF - 1.41 MB ]