Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Details

• Alternative Title:
  Drug Resist Updat
• Personal Author:
  Verweij, Paul E. ; Arendrup, Maiken C. ; Alastruey-Izquierdo, Ana ; Gold, Jeremy A.W. ; Lockhart, Shawn R. ; Chiller, Tom ; White, P.Lewis
• Description:
  Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.
• Keywords:
  Agriculture Antifungal Agents Aspergillus Fumigatus Azoles DHODH Inhibitor Drug Resistance, Fungal Fungicides, Industrial Humans Microbial Sensitivity Tests Olorofim One Health Triazole Resistance

  More +
• Source:
  Drug Resist Updat. 65:100885
• Pubmed ID:
  36283187
• Pubmed Central ID:
  PMC10693676
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  65
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6d47ea77f08d131ebde8c7374185f4442ae975d2123086d1bebed0ac0eeb7687
• Download URL:
  https://stacks.cdc.gov/view/cdc/136222/cdc_136222_DS1.pdf
• File Type:
  [PDF - 99.05 KB ]