Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Merker, Matthias ; Nikolaevskaya, Elena ; Kohl, Thomas A. ; Molina-Moya, Barbara ; Pavlovska, Olha ; Brännberg, Patrik ; Dudnyk, Andrii ; Stokich, Valentyna ; Barilar, Ivan ; Marynova, Iryna ; Filipova, Tetiana ; Prat, Cristina ; Sjöstedt, Anders ; Dominguez, Jose ; Rzhepishevska, Olena ; Niemann, Stefan
• Description:
  Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.
• Subjects:
  Antimicrobial Resistance Beijing Lineage Contact Tracing Drug Resistance MDR TB Multidrug- And Extensively Drug-Resistant Mycobacterium Tuberculosis Beijing Clades, Ukraine, 2015 Mycobacterium Tuberculosis Research Tuberculosis Tuberculosis And Other Mycobacteria Whole-genome Sequencing XDR TB

  More +
• Source:
  Emerg Infect Dis. 26(3):481-490
• Pubmed ID:
  32091369
• Pubmed Central ID:
  PMC7045844
• Document Type:
  Journal Article
• Place as Subject:
  Ukraine
• Location:
  Europe
• Volume:
  26
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9f8bd5eeb10930bff68bcd011f80224e944a3bc50c430bd9c2a103ada3e3bdd6
• Download URL:
  https://stacks.cdc.gov/view/cdc/85667/cdc_85667_DS1.pdf
• File Type:
  [PDF - 2.60 MB ]