Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia

Günther, Gunar; Mhuulu, Lusia; Diergaardt, Azaria; Dreyer, Viola; Moses, Maria; Anyolo, Kaarna; Ruswa, Nunurai; Claassens, Mareli; Niemann, Stefan; Nepolo, Emmanuel

doi:10.3201/eid3003.240134

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Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia

3 2024
By Günther, Gunar ; Mhuulu, Lusia ; Diergaardt, Azaria ; ...
http://dx.doi.org/10.3201/eid3003.240134
Source: Emerg Infect Dis. 2024; 30(3):568-571

[PDF-891.66 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Günther, Gunar ; Mhuulu, Lusia ; Diergaardt, Azaria ; Dreyer, Viola ; Moses, Maria ; ... More +

Günther, Gunar ; Mhuulu, Lusia ; Diergaardt, Azaria ; Dreyer, Viola ; Moses, Maria ; Anyolo, Kaarna ; Ruswa, Nunurai ; Claassens, Mareli ; Niemann, Stefan ; Nepolo, Emmanuel Less -
Description:

Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and adherence. The report highlights the risk for bedaquiline resistance development and the need for rapid drug-resistance testing.
Subjects:

[+]

Diarylquinolines/therapeutic Use Humans Treatment Outcome Tuberculosis, Multidrug-Resistant/drug Therapy
Keywords:

[+]

Antimicrobial Resistance Bacteria Bedaquiline MDR TB Namibia Respiratory Infections TB Tuberculosis Tuberculosis And Other Mycobacteria
Source:

Emerg Infect Dis. 2024; 30(3):568-571
Pubmed ID:

38407158
Pubmed Central ID:

PMC10902537
Document Type:

Journal Article
Place as Subject:

Namibia
Volume:

30
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:0bc94f339b128fa868dd8f478165295f7e4c49b54d27a872c56353e0e47bbf07
Download URL:

https://stacks.cdc.gov/view/cdc/148805/cdc_148805_DS1.pdf
File Type:

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