Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Günther, Gunar ; Mhuulu, Lusia ; Diergaardt, Azaria ; Dreyer, Viola ; Moses, Maria ; Anyolo, Kaarna ; Ruswa, Nunurai ; Claassens, Mareli ; Niemann, Stefan ; Nepolo, Emmanuel
• Description:
  Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and adherence. The report highlights the risk for bedaquiline resistance development and the need for rapid drug-resistance testing.
• Subjects:
  Diarylquinolines/therapeutic Use Humans Treatment Outcome Tuberculosis, Multidrug-Resistant/drug Therapy
• Keywords:
  Antimicrobial Resistance Bacteria Bedaquiline MDR TB Namibia Respiratory Infections TB Tuberculosis Tuberculosis And Other Mycobacteria
• Source:
  Emerg Infect Dis. 2024; 30(3):568-571
• Pubmed ID:
  38407158
• Pubmed Central ID:
  PMC10902537
• Document Type:
  Journal Article
• Place as Subject:
  Namibia
• Volume:
  30
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0bc94f339b128fa868dd8f478165295f7e4c49b54d27a872c56353e0e47bbf07
• Download URL:
  https://stacks.cdc.gov/view/cdc/148805/cdc_148805_DS1.pdf
• File Type:
  [PDF - 891.66 KB ]