Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort

Details

• Alternative Title:
  Sci Total Environ
• Personal Author:
  Aker, Amira ; McConnell, Rafael E Rios ; Loch-Caruso, Rita ; Park, Sung Kyun ; Mukherjee, Bhramar ; Rosario, Zaira Y ; Vélez-Vega, Carmen M ; Huerta-Montanez, Gredia ; Alshawabkeh, Akram N ; Cordero, José F ; Meeker, John D
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• Description:
  Background: ; Phenols and parabens are common additives to consumer products. There is evidence of adverse birth outcomes in association with prenatal exposure to these chemicals, in addition to psychosocial factors. We previously reported an increase in gestational length with bisphenol-A, methylparaben and propylparaben, and a decrease in gestational length with triclocarban. ; Objectives: ; We examined the modifying effect of psychosocial stress on the association between chemicals and gestational length in up to 752 women among a pregnancy cohort study. ; Methods: ; Urinary biomarkers were measured at up to three time points in pregnancy. Multiple linear regression models were conducted to investigate the association between gestational length and the interaction between average exposure biomarkers and LES. Multiple linear regression models regressing the exposure biomarkers in relation to gestational length were also stratified by LES, Negative LES, and Positive LES, based on the subjective ratings of events. Results were transformed into the change in gestational length for an inter-quartile-range difference in the exposure. ; Results: ; Of the four psychosocial stress measures, only the life events score (LES) was a significant modifier. Associations between triclocarban, bisphenol-S, methyl- and propylparaben in relation to gestational length were stronger among women with negative Total LES scores. Among women with negative Total LES scores, bisphenol-S and triclocarban were associated with a 3-5 day decrease in gestational length (−3.15; 95% CI:−6.06, −0.24); (−4.68; 95% CI: −8.47, −0.89), whereas methylparaben and propylparaben were associated with a 2-3 day increase in gestational length (2.21; 95% CI: 0.02, 4.40); (2.92; 95% CI: 0.58, 5.26). Significant interactions were driven by negative life events, but the association with triclocarban was driven by few positive life events. ; Conclusions: ; Associations between exposure biomarkers and gestational length were stronger in the presence of negative life events. This provides evidence that stress makes the body more vulnerable to chemical exposure.
• Subjects:
  • Adult
  • Carbanilides
  • Cohort Studies
  • Female
  • Hispanic or Latino
  • Humans
  • Maternal Exposure
  • Parabens
  • Phenols
  • Pregnancy
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• Source:
  Sci Total Environ. 708:134719
• Pubmed ID:
  31785910
• Pubmed Central ID:
  PMC6957748
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHS/United States ; UG3 OD023251/OD/NIH HHS/United States ; P30 ES017885/ES/NIEHS NIH HHS/United States ; UH3 OD023251/OD/NIH HHS/United States ; P42 ES017198/ES/NIEHS NIH HHS/United States ; P50 ES026049/ES/NIEHS NIH HHS/United States
• Place as Subject:
  Puerto Rico
• Volume:
  708
• Download URL:
  https://stacks.cdc.gov/view/cdc/84923/cdc_84923_DS1.pdf
• File Type:
  [PDF - 738.58 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4f239e57d52d69209785d0f07116c32e94702d315e0bf3f797b92e474db0ccc4