Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nguyet, Lam Anh ; Thanh, Tran Tan ; Nhan, Le Nguyen Thanh ; Hong, Nguyen Thi Thu ; Nhu, Le Nguyen Truc ; Van, Hoang Minh Tu ; Ny, Nguyen Thi Han ; Anh, Nguyen To ; Han, Do Duong Kim ; Tuan, Ha Manh ; Huy, Vu Quang ; Viet, Ho Lu ; Cuong, Hoang Quoc ; Thao, Nguyen Thi Thanh ; Viet, Do Chau ; Khanh, Truong Huu ; Thwaites, Louise ; Clapham, Hannah ; Hung, Nguyen Thanh ; Chau, Nguyen Van Vinh ; Thwaites, Guy ; Ha, Do Quang ; van Doorn, H. Rogier ; Tan, Le Van
• Description:
  Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from <60% at enrollment to 97%-100% at follow-up, corresponding to seroconversion rates of 57%-93%. Seroconversion for heterotypic viruses was recorded in only 3%-23% of patients. All plasma samples from patients infected with EV-A71 subgenogroup B5 could neutralize the emerging EV-A71 subgenogroup C4. Collectively, our results support previous reports about the potential benefit of EV-A71 vaccine but highlight the necessity of multivalent vaccines to control HFMD.
• Subjects:
  Coxsackievirus Enterovirus Enterovirus A71 Hand Foot And Mouth Disease HFMD Neutralization Neutralizing Antibodies Against Enteroviruses In Patients With Hand, Foot And Mouth Disease Research Viruses
• Source:
  Emerg Infect Dis. 26(2):298-306
• Pubmed ID:
  31961293
• Pubmed Central ID:
  PMC6986819
• Document Type:
  Journal Article
• Place as Subject:
  Vietnam
• Location:
  Asia
• Volume:
  26
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8bcc4e05eb0a389f38e20b6fcbeb292a11e3748a0c4e6a108fa209f69261dca6
• Download URL:
  https://stacks.cdc.gov/view/cdc/84831/cdc_84831_DS1.pdf
• File Type:
  [PDF - 724.16 KB ]