Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain

Skinner, Andrew M.; Petrella, Laurica; Siddiqui, Farida; Sambol, Susan P.; Gulvik, Christopher A.; Gerding, Dale N.; Donskey, Curtis J.; Johnson, Stuart

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Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain

Feb 2020
By Skinner, Andrew M. ; Petrella, Laurica ; Siddiqui, Farida ; ...
Source: Emerg Infect Dis. 26(2):247-254

[PDF-1.16 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Skinner, Andrew M. ; Petrella, Laurica ; Siddiqui, Farida ; Sambol, Susan P. ; Gulvik, Christopher A. ; ... More +

Skinner, Andrew M. ; Petrella, Laurica ; Siddiqui, Farida ; Sambol, Susan P. ; Gulvik, Christopher A. ; Gerding, Dale N. ; Donskey, Curtis J. ; Johnson, Stuart Less -
Description:

During a surveillance study of patients in a long-term care facility and the affiliated acute care hospital in the United States, we identified a Clostridioides difficile strain related to the epidemic PCR ribotype (RT) 027 strain associated with hospital outbreaks of severe disease. Fifteen patients were infected with this strain, characterized as restriction endonuclease analysis group DQ and RT591. Like RT027, DQ/RT591 contained genes for toxin B and binary toxin CDT and a tcdC gene of identical sequence. Whole-genome sequencing and multilocus sequence typing showed that DQ/RT591 is a member of the same multilocus sequence typing clade 2 as RT027 but in a separate cluster. DQ/RT591 produced a similar cytopathic effect as RT027 but showed delayed toxin production in vitro. DQ/RT591 was susceptible to moxifloxacin but highly resistant to clindamycin. Continued surveillance is warranted for this clindamycin-resistant strain that is related to the fluoroquinolone-resistant epidemic RT027 strain.
Subjects:

[+]

Aged Aged, 80 And Over Anti-Bacterial Agents Clindamycin Clostridioides Difficile Drug Resistance, Bacterial Enterocolitis, Pseudomembranous Feces Female Humans Long-Term Care Male Polymerase Chain Reaction Whole Genome Sequencing
Source:

Emerg Infect Dis. 26(2):247-254
Pubmed ID:

31961290
Pubmed Central ID:

PMC6986856
Document Type:

Journal Article
Place as Subject:

Illinois ; Ohio

Illinois ; Ohio Less -
Location:

North America
Volume:

26
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:461b6fc210bb38d8d11841adad2ecc85bbe23ee80149594a265dac1e1efaeaef
Download URL:

https://stacks.cdc.gov/view/cdc/84815/cdc_84815_DS1.pdf
File Type:

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