Temporal Changes in Resistance Mechanisms in Colonizing Escherichia coli Isolates with Reduced Susceptibility to Fluoroquinolones

Han, Jennifer H.; Nachamkin, Irving; Tolomeo, Pam; Mao, Xiangqun; Bilker, Warren B.; Lautenbach, Ebbing

doi:10.1016/j.diagmicrobio.2013.04.018

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Temporal Changes in Resistance Mechanisms in Colonizing Escherichia coli Isolates with Reduced Susceptibility to Fluoroquinolones

8-2013
By Han, Jennifer H. ; Nachamkin, Irving ; Tolomeo, Pam ; ...
http://dx.doi.org/10.1016/j.diagmicrobio.2013.04.018
Source: Diagn Microbiol Infect Dis. 2013; 76(4):491-496

[PDF-384.09 KB]

English

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Details:

Alternative Title:

Diagn Microbiol Infect Dis
Personal Author:

Han, Jennifer H. ; Nachamkin, Irving ; Tolomeo, Pam ; Mao, Xiangqun ; Bilker, Warren B. ; ... More +

Han, Jennifer H. ; Nachamkin, Irving ; Tolomeo, Pam ; Mao, Xiangqun ; Bilker, Warren B. ; Lautenbach, Ebbing Less -
Description:

The objective of this study was to characterize the temporal variability of fluoroquinolone resistance mechanisms among Escherichia coli colonizing the gastrointestinal tract of hospitalized patients. Patients with new fluoroquinolone-resistant E. coli (FQREC) colonization were followed with serial fecal sampling until discharge or death. Genetic mechanism(s) of resistance for all FQREC isolates was characterized, including mutations in gyrA and parC and efflux pump overexpression. Of 451 subjects, 73 (16.2%) became newly colonized with FQREC. There was significant variability in regard to temporal changes in resistance mechanisms and levofloxacin MICs among isolates from individual patients. Compared to patients with transient colonization, patients with persistent colonization were more likely to have a urinary catheter (P = 0.04), diarrhea (P = 0.04), and a longer duration of hospitalization (22 and 9.0 mean days, respectively; P = 0.01) prior to sampling. Our data demonstrate the significant variability of resistance mechanisms in colonizing E. coli isolates among hospitalized patients.
Keywords:

[+]

Adult Aged Aged, 80 And Over Anti-Bacterial Agents Bacterial Proteins DNA Gyrase DNA Topoisomerase IV Drug Resistance, Bacterial Escherichia Coli Escherichia Coli Infections Feces Female Fluoroquinolones Gastrointestinal Tract Hospitalization Humans Male Membrane Transport Proteins Microbial Sensitivity Tests Middle Aged Mutation Time Factors
Source:

Diagn Microbiol Infect Dis. 2013; 76(4):491-496
Pubmed ID:

23719087
Pubmed Central ID:

PMC3725193
Document Type:

Journal Article
Funding:

K24 AI080942/AI/NIAID NIH HHSUnited States/ ; U54CK000163/ACL/ACL HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; RS1/CCR320627-01/RS/DRS NIH HHSUnited States/ ; U54-CK000163/CK/NCEZID CDC HHSUnited States/

K24 AI080942/AI/NIAID NIH HHSUnited States/ ; U54CK000163/ACL/ACL HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; RS1/CCR320627-01/RS/DRS NIH HHSUnited States/ ; U54-CK000163/CK/NCEZID CDC HHSUnited States/ Less -
Volume:

76
Issue:

4
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:999773ef6c2121c8db4e3779417c8965f81650e7c0f3e9e8305ec8b691c9dbeb
Download URL:

https://stacks.cdc.gov/view/cdc/29695/cdc_29695_DS1.pdf
File Type:

	nihms-474546-f0001.gif	gif
	nihms-474546-f0001.jpg	jpeg
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