Night-shift work duration and risk of colorectal cancer according to IRS1 and IRS2 expression

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Shi, Yan ; Liu, Li ; Hamada, Tsuyoshi ; Nowak, Jonathan A ; Giannakis, Marios ; Ma, Yanan ; Song, Mingyang ; Nevo, Daniel ; Kosumi, Keisuke ; Gu, Mancang ; Kim, Sun A. ; Morikawa, Teppei ; Wu, Kana ; Sui, Jing ; Papantoniou, Kyriaki ; Wang, Molin ; Chan, Andrew T. ; Fuchs, Charles S. ; Meyerhardt, Jeffrey A. ; Giovannucci, Edward ; Ogino, Shuji ; Schernhammer, Eva S. ; Nishihara, Reiko ; Zhang, Xuehong
• Description:
  Objective:
  
  We hypothesized that the risk of CRC in night-shift workers might be different according to insulin receptor substrates status.
  
  Methods:
  
  Among 77,470 eligible women having night work assessed in the Nurses’ Health Study, we documented a total of 1,397 CRC cases, of which 304 or 308 had available data on IRS1 and IRS2, respectively. We used duplication method Cox proportional hazards regression analysis for competing risks to calculate HRs and 95% CIs for each CRC subtype. We measured tumor IRS1 or IRS2 expression by immunohistochemistry.
  
  Results:
  
  Compared with women who never worked night-shifts, those working ≥ 15 years night-shifts had a marginal trend of increased overall risk of CRC (Ptrend = 0.06, multivariable HR = 1.20, 95% CI, 0.99 to 1.45). Longer duration of night-shift work was associated with a higher risk of IRS2-positive tumors (multivariable HR = 2.69, 95% CI 1.48 to 4.89, Ptrend = 0.001, ≥ 15 years night-shifts vs. never) but not with IRS2-negative tumors (multivariable HR = 0.90, 95% CI 0.54 to 1.51, Ptrend = 0.72, Pheterogeneity for IRS2 = 0.008). Similarly, the corresponding multivariable HRs were 1.81 for IRS1-positive tumors (95% CI 0.94 to 3.48, Ptrend = 0.06) and 1.13 for IRS1-negative tumors (95% CI 0.71 to 1.80, Ptrend = 0.56, Pheterogeneity for IRS1 = 0.02).
  
  Conclusion:
  
  Our molecular pathological epidemiology data suggest a potential role of IRS in mediating carcinogenesis induced by night-shift work.
  
  Impact:
  
  Although these findings need validation, rotating night-shift might increase CRC risk in women with abnormal insulin receptor pathway.
  
  
• Subjects:
  Biomarkers, Tumor Carcinogenesis Colon Colorectal Neoplasms Female Humans Immunohistochemistry Insulin Receptor Substrate Proteins Middle Aged Molecular Epidemiology Nurses Rectum Risk Assessment Risk Factors Shift Work Schedule Time Factors

  More +
• Keywords:
  Cancer Prevention Circadian Disruption Cohort Study Colon Cancer Etiologic Heterogeneity Insulin Receptor Substrate Metabolism Molecular Pathological Epidemiology Rectal Cancer Rotating Night-shift Work
• Source:
  Cancer Epidemiol Biomarkers Prev. 29(1):133-140
• Pubmed ID:
  31666286
• Pubmed Central ID:
  PMC6954315
• Document Type:
  Journal Article
• Funding:
  R35 CA197735/CA/NCI NIH HHSUnited States/ ; R01 CA151993/CA/NCI NIH HHSUnited States/ ; R01 CA137178/CA/NCI NIH HHSUnited States/ ; K24 DK098311/DK/NIDDK NIH HHSUnited States/ ; UM1 CA186107/CA/NCI NIH HHSUnited States/ ; R01 CA169141/CA/NCI NIH HHSUnited States/ ; K07 CA188126/CA/NCI NIH HHSUnited States/ ; R03 CA176717/CA/NCI NIH HHSUnited States/ ; P50 CA127003/CA/NCI NIH HHSUnited States/ ; K07 CA190673/CA/NCI NIH HHSUnited States/ ; R01 OH009803/OH/NIOSH CDC HHSUnited States/ ; P01 CA087969/CA/NCI NIH HHSUnited States/
• Volume:
  29
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c0c74dfcc53dfdc956864c0abca84f2cb10fa78b052f992308e1385e8eaa9531
• Download URL:
  https://stacks.cdc.gov/view/cdc/84128/cdc_84128_DS1.pdf
• File Type:
  [PDF - 400.04 KB ]