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Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019
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November 17 2019
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Source: Emerg Infect Dis. 25(11):2108-2111
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Alternative Title:Emerg Infect Dis
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Description:In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.
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Pubmed ID:31436527
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Pubmed Central ID:PMC6810216
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Volume:25
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Issue:11
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