Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

Takashita, Emi; Ichikawa, Masataka; Morita, Hiroko; Ogawa, Rie; Fujisaki, Seiichiro; Shirakura, Masayuki; Miura, Hideka; Nakamura, Kazuya; Kishida, Noriko; Kuwahara, Tomoko; Sugawara, Hiromi; Sato, Aya; Akimoto, Miki; Mitamura, Keiko; Abe, Takashi; Yamazaki, Masahiko; Watanabe, Shinji; Hasegawa, Hideki; Odagiri, Takato

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Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

November 17 2019
By Takashita, Emi ; Ichikawa, Masataka ; Morita, Hiroko ; ...
Source: Emerg Infect Dis. 25(11):2108-2111

[PDF-1000.39 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Takashita, Emi ; Ichikawa, Masataka ; Morita, Hiroko ; Ogawa, Rie ; Fujisaki, Seiichiro ; ... More +

Takashita, Emi ; Ichikawa, Masataka ; Morita, Hiroko ; Ogawa, Rie ; Fujisaki, Seiichiro ; Shirakura, Masayuki ; Miura, Hideka ; Nakamura, Kazuya ; Kishida, Noriko ; Kuwahara, Tomoko ; Sugawara, Hiromi ; Sato, Aya ; Akimoto, Miki ; Mitamura, Keiko ; Abe, Takashi ; Yamazaki, Masahiko ; Watanabe, Shinji ; Hasegawa, Hideki ; Odagiri, Takato Less -
Description:

In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.
Subjects:

[+]

Antimicrobial Resistance Baloxavir Baloxavir Acid Baloxavir Marboxil Cap-dependent Endonuclease Inhibitor Dispatch Family Cluster H3N2 Human-to-human Transmission Human-to-Human Transmission Of Influenza A(H3N2) Virus With Reduced Susceptibility To Baloxavir, Japan, February 2019 I38T Substitution Influenza Influenza A(H1N1)pdm09 Influenza Virus Polymerase Acidic Respiratory Infections Viruses Whole-genome Sequencing
Source:

Emerg Infect Dis. 25(11):2108-2111
Pubmed ID:

31436527
Pubmed Central ID:

PMC6810216
Document Type:

Journal Article
Place as Subject:

Japan
Location:

Asia
Volume:

25
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:1ff228287a2d097f9a6f5d1c7bdf3603cdc7c169ec1bd986f4e7aaa3be649fff
Download URL:

https://stacks.cdc.gov/view/cdc/83010/cdc_83010_DS1.pdf
File Type:

	19-0757-F.gif	gif
	19-0757-F.jpg	jpeg
	19-0757.nxml	xml

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