Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Takashita, Emi ; Ichikawa, Masataka ; Morita, Hiroko ; Ogawa, Rie ; Fujisaki, Seiichiro ; Shirakura, Masayuki ; Miura, Hideka ; Nakamura, Kazuya ; Kishida, Noriko ; Kuwahara, Tomoko ; Sugawara, Hiromi ; Sato, Aya ; Akimoto, Miki ; Mitamura, Keiko ; Abe, Takashi ; Yamazaki, Masahiko ; Watanabe, Shinji ; Hasegawa, Hideki ; Odagiri, Takato
• Description:
  In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.
• Subjects:
  Antimicrobial Resistance Baloxavir Baloxavir Acid Baloxavir Marboxil Cap-dependent Endonuclease Inhibitor Dispatch Family Cluster H3N2 Human-to-human Transmission Human-to-Human Transmission Of Influenza A(H3N2) Virus With Reduced Susceptibility To Baloxavir, Japan, February 2019 I38T Substitution Influenza Influenza A(H1N1)pdm09 Influenza Virus Polymerase Acidic Respiratory Infections Viruses Whole-genome Sequencing

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• Source:
  Emerg Infect Dis. 25(11):2108-2111
• Pubmed ID:
  31436527
• Pubmed Central ID:
  PMC6810216
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Location:
  Asia
• Volume:
  25
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1ff228287a2d097f9a6f5d1c7bdf3603cdc7c169ec1bd986f4e7aaa3be649fff
• Download URL:
  https://stacks.cdc.gov/view/cdc/83010/cdc_83010_DS1.pdf
• File Type:
  [PDF - 1000.39 KB ]