Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy

Medrano, Chloé; Vergez, François; Mengelle, Catherine; Faguer, Stanislas; Kamar, Nassim; Del Bello, Arnaud

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Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy

November 2019
By Medrano, Chloé ; Vergez, François ; Mengelle, Catherine ; ...
Source: Emerg Infect Dis. 25(11):2145-2147

[PDF-379.12 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Medrano, Chloé ; Vergez, François ; Mengelle, Catherine ; Faguer, Stanislas ; Kamar, Nassim ; ... More +

Medrano, Chloé ; Vergez, François ; Mengelle, Catherine ; Faguer, Stanislas ; Kamar, Nassim ; Del Bello, Arnaud Less -
Description:

Antibodies against PD1 have been used to treat progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus. We used these antibodies (nivolumab) to treat PML in 3 kidney transplant recipients. All died within 8 weeks of diagnosis. Hence, nivolumab did not improve PML outcome after solid organ transplantation.
Subjects:

[+]

Antineoplastic Agents, Immunological Humans Immunomodulation Jc Virus Kidney Transplantation Leukoencephalopathy, Progressive Multifocal Nivolumab Transplant Recipients Treatment Outcome
Source:

Emerg Infect Dis. 25(11):2145-2147
Pubmed ID:

31625858
Pubmed Central ID:

PMC6810212
Document Type:

Journal Article
Genre:

Letter
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:30f342baad78a586d9f59c73d44edbf96efffba10eb23be6f167fc7da93a9a75
Download URL:

https://stacks.cdc.gov/view/cdc/83006/cdc_83006_DS1.pdf
File Type:

	19-0705-Techapp-s1.pdf	pdf
	19-0705.nxml	xml

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