Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Medrano, Chloé ; Vergez, François ; Mengelle, Catherine ; Faguer, Stanislas ; Kamar, Nassim ; Del Bello, Arnaud
• Description:
  Antibodies against PD1 have been used to treat progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus. We used these antibodies (nivolumab) to treat PML in 3 kidney transplant recipients. All died within 8 weeks of diagnosis. Hence, nivolumab did not improve PML outcome after solid organ transplantation.
• Subjects:
  Antineoplastic Agents, Immunological Humans Immunomodulation Jc Virus Kidney Transplantation Leukoencephalopathy, Progressive Multifocal Nivolumab Transplant Recipients Treatment Outcome
• Source:
  Emerg Infect Dis. 25(11):2145-2147
• Pubmed ID:
  31625858
• Pubmed Central ID:
  PMC6810212
• Document Type:
  Journal Article
• Genre:
  Letter
• Volume:
  25
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:30f342baad78a586d9f59c73d44edbf96efffba10eb23be6f167fc7da93a9a75
• Download URL:
  https://stacks.cdc.gov/view/cdc/83006/cdc_83006_DS1.pdf
• File Type:
  [PDF - 379.12 KB ]