Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab

Martinot, Martin; Ahle, Guido; Petrosyan, Inesa; Martinez, Camille; Gorun, Dragos M.; Mohseni-Zadeh, Mahsa; Fafi-Kremer, Samira; Tebacher-Alt, Martine

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Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab

Supporting Files Public Domain

August 2018
By Martinot, Martin ; Ahle, Guido ; Petrosyan, Inesa ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Martinot, Martin ; Ahle, Guido ; Petrosyan, Inesa ; Martinez, Camille ; Gorun, Dragos M. ; Mohseni-Zadeh, Mahsa ; Fafi-Kremer, Samira ; Tebacher-Alt, Martine
Description:

Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cancer and infections. Data for 4 other cases were obtained from pharmacovigilance databases.
Subjects:

Aged Antineoplastic Agents, Immunological Antineoplastic Combined Chemotherapy Protocols Female Hodgkin Disease Humans Hydrocortisone Jc Virus Leukoencephalopathy, Progressive Multifocal Magnetic Resonance Imaging Male Middle Aged Nivolumab Programmed Cell Death 1 Receptor Viremia
Source:

Emerg Infect Dis. 24(8):1594-1596
Pubmed ID:

30016251
Pubmed Central ID:

PMC6056118
Document Type:

Journal Article
Genre:

Letter
Volume:

24
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:063d5cdef19967f75ac7e2c46f356e3ab5066f8c4084508ae852f829da1ae82d
Download URL:

https://stacks.cdc.gov/view/cdc/57980/cdc_57980_DS1.pdf
File Type:

[PDF - 605.97 KB ]

File Language:

English

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