Vitamin D metabolic loci and vitamin D status in Black and White pregnant women

Details

• Alternative Title:
  Eur J Obstet Gynecol Reprod Biol
• Personal Author:
  Baca, Katharyn M. ; Govil, Manika ; Zmuda, Joseph M. ; Simhan, Hyagriv N. ; Marazita, Mary L. ; Bodnar, Lisa M.
• Description:
  Background
  
  Several candidate genes and genome wide association studies have reported significant associations between vitamin D metabolism genes and 25-hydroxyvitamin D. Few studies have examined these relationships in pregnancy.
  
  Objective
  
  We evaluated the relationship between maternal allelic variants in three vitamin D metabolism genes and 25-hydroxyvitamin D (25(OH)D) concentration in pregnancy.
  
  Study design
  
  In two case-control studies, samples were drawn from women who delivered at Magee Womens Hospital in Pittsburgh, PA from 1999 to 2010 and twelve recruiting sites across the United States from 1959 to 65. For 882 Black and 1796 White pregnant women from these studies, 25(OH)D concentration was measured and single nucleotide polymorphisms (SNPs) were genotyped 50 kilobases up- and down-stream in three genes (VDR, GC, and CYP27B1). Using multivariable linear regression, we estimated the associations between allelic variation of each locus and log-transformed 25(OH)D concentration separately by race and study group. Meta-analysis was used to estimate the association across the four groups for each SNP.
  
  Results
  
  Minor alleles of several variants in VDR, GC, and CYP27B1 were associated with differences in log-transformed 25(OH)D concentration compared to the corresponding major alleles [beta, 95% confidence intervals (CI)]. The meta-analysis confirmed the associations for differences in log-transformed 25(OH)D by allelic loci for one intron VDR variant [rs2853559 0.08 (0.02, 0.13), p < 0.01] and a variant in the GC flanking region [rs13150174: 0.04 (0.02, 0.07), p < 0.01], and a GC missense mutation [rs7041 0.05 (0.01, 0.09), p < 0.01]. The meta-analysis also revealed possible associations for SNPs in linkage disequilibrium with variants in the VDR 3-prime untranslated region, another GC missense variant (rs4588), and a variant of the 3-prime untranslated region of CYP27B1.
  
  Conclusion
  
  We observed associations between VDR, GC, and CYP27B1 variants and maternal 25-hydroxyvitamin D concentration. Our results provide additional support for a possible role of genetic variation in vitamin D metabolism genes on vitamin D status during pregnancy.
  
  
• Subjects:
  Adult Alleles Black People Case-Control Studies Female Genome-Wide Association Study Genotype Humans Linkage Disequilibrium Polymorphism, Single Nucleotide Pregnancy Receptors, Calcitriol Vitamin D-Binding Protein White People Young Adult

  More +
• Source:
  Eur J Obstet Gynecol Reprod Biol. 220:61-68
• Pubmed ID:
  29175129
• Pubmed Central ID:
  PMC6637415
• Document Type:
  Journal Article
• Funding:
  U01 DP003177/DP/NCCDPHP CDC HHS/United States
• Volume:
  220
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:818a9de38851070c02595920a4d813da07659db3ff642e1eae28f2d4c636fbf6
• Download URL:
  https://stacks.cdc.gov/view/cdc/79954/cdc_79954_DS1.pdf
• File Type:
  [PDF - 540.89 KB ]