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Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease
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Jun 2019
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Source: Emerg Infect Dis. 25(6):1144-1152
[PDF-3.41 MB]
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Alternative Title:Emerg Infect Dis
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Description:Nipah virus (NiV) is a zoonotic pathogen that causes high case-fatality rates (CFRs) in humans. Two NiV strains have caused outbreaks: the Malaysia strain (NiV|), discovered in 1998-1999 in Malaysia and Singapore (≈40% CFR); and the Bangladesh strain (NiV|), discovered in Bangladesh and India in 2001 (≈80% CFR). Recently, NiV| in African green monkeys resulted in a more severe and lethal disease than NiV|. No NiV vaccines or treatments are licensed for human use. We assessed replication-restricted single-injection recombinant vesicular stomatitis vaccine NiV vaccine vectors expressing the NiV glycoproteins against NiV| challenge in African green monkeys. All vaccinated animals survived to the study endpoint without signs of NiV disease; all showed development of NiV F Ig, NiV G IgG, or both, as well as neutralizing antibody titers. These data show protective efficacy against a stringent and relevant NiV| model of human infection.
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Pubmed ID:31107231
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Pubmed Central ID:PMC6537706
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Volume:25
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Issue:6
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