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Protective Efficacy of Lyophilized Vesicular Stomatitis Virus–Based Vaccines in Animal Model
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5 2024
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Source: Emerg Infect Dis. 2024; 30(5):1004-1008
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Alternative Title:Emerg Infect Dis
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Description:We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations.
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Pubmed ID:38666640
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Pubmed Central ID:PMC11060439
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Volume:30
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Issue:5
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