Protective Efficacy of Lyophilized Vesicular Stomatitis Virus–Based Vaccines in Animal Model

Salawudeen, Abd’jeleel; Soule, Geoff; Tailor, Nikesh; Klassen, Levi; Audet, Jonathan; Sloan, Angela; Deschambault, Yvon; Safronetz, David

doi:10.3201/eid3005.231248

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Protective Efficacy of Lyophilized Vesicular Stomatitis Virus–Based Vaccines in Animal Model

5 2024
By Salawudeen, Abd’jeleel ; Soule, Geoff ; Tailor, Nikesh ; ...
http://dx.doi.org/10.3201/eid3005.231248
Source: Emerg Infect Dis. 2024; 30(5):1004-1008

[PDF-1.56 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Salawudeen, Abd’jeleel ; Soule, Geoff ; Tailor, Nikesh ; Klassen, Levi ; Audet, Jonathan ; ... More +

Salawudeen, Abd’jeleel ; Soule, Geoff ; Tailor, Nikesh ; Klassen, Levi ; Audet, Jonathan ; Sloan, Angela ; Deschambault, Yvon ; Safronetz, David Less -
Description:

We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations.
Subjects:

[+]

Animals Antibodies, Viral Disease Models, Animal Freeze Drying Guinea Pigs Vaccine Efficacy Vesicular Stomatitis Vesicular Stomatitis Indiana Virus Vesiculovirus Viral Vaccines
Keywords:

[+]

Animal Models Ebola Virus Glycoproteins Guinea Pigs Lassa Virus Lyophilized Vaccines Vesicular Stomatitis Virus Viruses Zoonoses
Source:

Emerg Infect Dis. 2024; 30(5):1004-1008
Pubmed ID:

38666640
Pubmed Central ID:

PMC11060439
Document Type:

Journal Article
Genre:

Dispatch
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:a39d33133b1b99e8d00f062c3d5e10fa5d4cf37d994903a8c07323a79484e107
Download URL:

https://stacks.cdc.gov/view/cdc/154861/cdc_154861_DS1.pdf
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