Protective Efficacy of Lyophilized Vesicular Stomatitis Virus–Based Vaccines in Animal Model

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Salawudeen, Abd’jeleel ; Soule, Geoff ; Tailor, Nikesh ; Klassen, Levi ; Audet, Jonathan ; Sloan, Angela ; Deschambault, Yvon ; Safronetz, David
• Description:
  We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations.
• Subjects:
  Animals Antibodies, Viral Disease Models, Animal Freeze Drying Guinea Pigs Vaccine Efficacy Vesicular Stomatitis Vesicular Stomatitis Indiana Virus Vesiculovirus Viral Vaccines
• Keywords:
  Animal Models Ebola Virus Glycoproteins Guinea Pigs Lassa Virus Lyophilized Vaccines Vesicular Stomatitis Virus Viruses Zoonoses
• Source:
  Emerg Infect Dis. 2024; 30(5):1004-1008
• Pubmed ID:
  38666640
• Pubmed Central ID:
  PMC11060439
• Document Type:
  Journal Article
• Genre:
  Dispatch
• Volume:
  30
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a39d33133b1b99e8d00f062c3d5e10fa5d4cf37d994903a8c07323a79484e107
• Download URL:
  https://stacks.cdc.gov/view/cdc/154861/cdc_154861_DS1.pdf
• File Type:
  [PDF - 1.56 MB ]