Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model

Gary, Joy M.; Welch, Stephen R.; Ritter, Jana M.; Coleman-McCray, JoAnn; Huynh, Thanhthao; Kainulainen, Markus H.; Bollweg, Brigid C.; Parihar, Vaunita; Nichol, Stuart T.; Zaki, Sherif R.; Spiropoulou, Christina F.; Spengler, Jessica R.

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Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model

Published Date:

May 2019

Source:

Emerg Infect Dis. 25(5):865-874

Language:

English

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Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Gary, Joy M. ; Welch, Stephen R. ; Ritter, Jana M. ; Coleman-McCray, JoAnn ; Huynh, Thanhthao ; ... More ▼

Description:

Lassa virus (LASV), a hemorrhagic fever virus endemic to West Africa, causes conjunctivitis in patients with acute disease. To examine ocular manifestations of LASV, we histologically examined eyes from infected guinea pigs. In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). Antigen was primarily associated with infiltration of T-lymphocytes around vessels in the anterior uvea and with new vessel formation at the peripheral cornea. In animals that exhibited clinical signs but survived infection, eyes had little to no inflammation and no LASV immunostaining 6 weeks after infection. Overall, in this model, LASV antigen was restricted to the anterior uvea and was associated with mild chronic inflammation in animals with severe disease but was not detected in survivors.

Subject:

[+]

Pubmed ID:

31002065

Pubmed Central ID:

PMC6478213

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

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