Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys

Details

• Alternative Title:
  Int J Hyg Environ Health
• Personal Author:
  Marks, Kristin J. ; Cutler, Anya J. ; Jeddy, Zuha ; Northstone, Kate ; Kato, Kayoko ; Hartman, Terryl J.
• Description:
  Per- and polyfluoroalkyl substances (PFAS) have been widely used in commercial and industrial manufacturing processes since the 1950s. Inverse associations between prenatal exposure to PFAS and birth size have been found in populations around the globe. This study examined the association of prenatal maternal serum concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) and birth size in British boys. The study included 457 mother-son dyads participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Birth weight (g), crown to heel length (cm), and head circumference (cm) were collected at delivery. PFAS were detected in all maternal serum samples during pregnancy (median: 30 weeks gestation (interquartile range: 12-33)). Median concentrations (interquartile range) were 13.8 ng/mL (11.0, 17.7), 3.0 ng/mL (2.3, 3.8), 1.9 ng/mL (1.4, 2.5), and 0.4 ng/mL (0.3, 0.5) for PFOS, PFOA, PFHxS, and PFNA, respectively. In multivariable linear regression models, inverse associations were detected between PFOS (continuous) and birth weight (β = -8.50 g, 95% CI = -15.93, -1.07 g), crown to heel length (β = -0.04 cm, 95% CI = -0.08, -0.01 cm), and head circumference (β = -0.02 cm, 95% CI = -0.04, -0.002 cm). In conclusion, prenatal exposure to high levels of PFOS may be associated with reduced birth size in male infants.
• Subjects:
  Birth Size Birth Weight Female Fluorocarbons Humans Linear Models Longitudinal Studies Male Multivariate Analysis Pregnancy Prenatal Exposure Delayed Effects

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• Source:
  Int J Hyg Environ Health.
• Pubmed ID:
  30975573
• Pubmed Central ID:
  PMC6571162
• Document Type:
  Journal Article
• Funding:
  WT_/Wellcome Trust/United Kingdom ; CC999999/ImCDC/Intramural CDC HHS/United States ; G9815508/MRC_/Medical Research Council/United Kingdom ; 102215/2/13/2/WT_/Wellcome Trust/United Kingdom
• Place as Subject:
  United Kingdom
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4ea7c5c5990ba28ab6fc3d2e80bcbe926ead75330ecd1a34abb1030aafac795a
• Download URL:
  https://stacks.cdc.gov/view/cdc/79137/cdc_79137_DS1.pdf
• File Type:
  [PDF - 346.70 KB ]