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Maternal occupational exposure to selected organic and chlorinated solvents and delivery of small-for-gestational age or preterm infants
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10 2023
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Source: Am J Ind Med. 66(10):842-853
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Alternative Title:Am J Ind Med
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Description:Background:
Potential reproductive effects of organic solvent exposure during pregnancy remain unclear. We investigated the association between maternal occupational exposure during pregnancy to six chlorinated solvents, three aromatic solvents, and Stoddard solvent and delivery of preterm infants or those born small-for-gestational age (SGA).
Methods:
In this case-control study of SGA and preterm birth (PTB) nested within the National Birth Defects Prevention Study (NBDPS) from 1997–2011, we analyzed data from 7,504 singleton live births without major birth defects and their mothers. Self-reported information on jobs held in the periconceptional period were assessed for solvent exposure. Unconditional logistic regression was used to estimate the association between maternal occupational exposure (any, none) during early pregnancy to organic solvents and PTB and SGA. Linear regression was used to examine change in mean birthweight among infants potentially associated with maternal occupational solvent exposure.
Results:
Maternal occupational exposure to any organic solvents overall was not associated with an increased odds of PTB (aOR=0.94; 95% CI 0.67, 1.33) or SGA (aOR=0.93; 95% CI 0.65, 1.34). Point estimates increased modestly for higher estimated exposure versus lower, but confidence intervals were wide and not statistically significant. Maternal exposure to solvents was not associated with a statistically significant change in term birthweight among infants.
Conclusions:
Occupational exposure to organic solvents at the frequency and intensity levels found in a population-based sample of pregnant workers was not associated with PTB or SGA; however, we cannot rule out any effect(s) among pregnant workers with uncommonly high exposure to organic solvents.
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Pubmed ID:37463847
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Pubmed Central ID:PMC10527887
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