Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Daum, Luke T. ; Shaw, Michael W. ; Klimov, Alexander I. ; Canas, Linda C. ; Macias, Elizabeth A. ; ... More +
Daum, Luke T. ; Shaw, Michael W. ; Klimov, Alexander I. ; Canas, Linda C. ; Macias, Elizabeth A. ; Niemeyer, Debra ; Chambers, James P. ; Renthal, Robert ; Shrestha, Sanjaya K. ; Acharya, Ramesh P. ; Huzdar, Shankar P. ; Rimal, Nirmal ; Myint, Khin S. ; Gould, Philip Less -
Description:
In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that approximately 40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005-2006 influenza season. Thus, the 2005-2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates.
Subject:
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Amino Acid Sequence Antigenic Variation Child Disease Outbreaks Female Genetic Drift H3N2 Hemagglutination Inhibition Tests Hemagglutinin Hemagglutinins Humans Influenza, Human Influenza A Virus Influenza A Virus, H3N2 Subtype Keywords: Influena A Male Models, Molecular Molecular Sequence Data Nepal Phylogeny Research Reverse Transcriptase Polymerase Chain Reaction RNA, Viral Sequence Alignment Sequence Analysis, DNA Variant
Source:
Emerg Infect Dis. 11(8):1186-1191.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:8ba4e69272d50144251e91c85d3b4859ae23da40da29d8aa47ef878e0151cc73
Download URL:
https://stacks.cdc.gov/view/cdc/7874/cdc_7874_DS1.pdf
File Type:

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