Influenza A (H3N2) Outbreak, Nepal

Daum, Luke T.; Shaw, Michael W.; Klimov, Alexander I.; Canas, Linda C.; Macias, Elizabeth A.; Niemeyer, Debra; Chambers, James P.; Renthal, Robert; Shrestha, Sanjaya K.; Acharya, Ramesh P.; Huzdar, Shankar P.; Rimal, Nirmal; Myint, Khin S.; Gould, Philip

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Influenza A (H3N2) Outbreak, Nepal

Published Date:

Aug 2005

Source:

Emerg Infect Dis. 11(8):1186-1191.

[PDF-331.77 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Daum, Luke T. ; Shaw, Michael W. ; Klimov, Alexander I. ; Canas, Linda C. ; Macias, Elizabeth A. ; ... More ▼

Description:

In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that approximately 40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005-2006 influenza season. Thus, the 2005-2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	05-0302-F1.gif	image/gif
	05-0302-F1.jpg	image/jpeg
	05-0302-F2.gif	image/gif
	05-0302-F2.jpg	image/jpeg
	05-0302-F3.gif	image/gif
	05-0302-F3.jpg	image/jpeg
	05-0302.nxml	text/plain

No Related Documents.

You May Also Like:

Outbreak of influenza in highly vaccinated crew of U.S. Navy ship.

Personal Author:

Earhart, K. C.; Beadle, C.; Miller, L. K.; Pruss, M. W.; Gray, G. C.; Ledbetter, E. K.; Wallace, M. R.;

Published Date:

2001 May-Jun

Source:

Emerg Infect Dis. 7(3):463-465.

Description:

An outbreak of influenza A (H3N2) occurred aboard a U.S. Navy ship in February 1996, despite 95% of the crew's having been appropriately vaccinated. Virus isolated from ill crew members was antigenically distinct from the vaccination strain. With an ...

File Type:

[PDF - 41.40 KB]
Etymologia: Cephalosporin

Published Date:

Aug 2005

Source:

Emerg Infect Dis. 11(8):1191.

File Type:

[PDF - 33.27 KB]
MMWR. Morbidity and mortality weekly report, Vol. 63, no. 39, October 3, 2014

Corporate Authors:

Centers for Disease Control and Prevention (U.S.)

Published Date:

October 3, 2014

Series:

MMWR. Morbidity and mortality weekly report ; v. 63, no. 39

File Type:

[PDF - 2.50 MB]
Genomic Signature-Based Identification of Influenza A Viruses Using RT-PCR/Electro-Spray Ionization Mass Spectrometry (ESI-MS) Technology

Personal Author:

Deyde, Varough M.; Sampath, Rangarajan; Garten, Rebecca J.; Blair, Patrick J.; Myers, Christopher A.; Massire, Christian; Matthews, Heather; Svoboda, Pavel; Reed, Matthew S.; Pohl, Jan; Klimov, Alexander I.; Gubareva, Larisa V.;

Published Date:

October 12 2010

Source:

PLoS One. 2010; 5(10)

Description:

BackgroundThe emergence and rapid spread of the 2009 H1N1 pandemic influenza A virus (H1N1pdm) in humans highlights the importance of enhancing the capability of existing influenza surveillance systems with tools for rapid identification of emerging ...

File Type:

[PDF - 3.77 MB]
Avian Influenza A(H7N9) Virus Antibodies in Close Contacts of Infected Persons, China, 2013–2014

Personal Author:

Ma, Mai-Juan; Ma, Guang-Yuan; Yang, Xiao-Xian; Chen, Shan-Hui; Gray, Gregory C.; Zhao, Teng; Bao, Jing; Zhou, Jing-Jing; Qian, Yan-Hua; Lu, Bin; Ling, Xia; Cao, Wu-Chun;

Published Date:

Apr 2015

Source:

Emerg Infect Dis. 21(4):709-711.

File Type:

[PDF - 297.34 KB]