Influenza A (H3N2) Outbreak, Nepal

Daum, Luke T.; Shaw, Michael W.; Klimov, Alexander I.; Canas, Linda C.; Macias, Elizabeth A.; Niemeyer, Debra; Chambers, James P.; Renthal, Robert; Shrestha, Sanjaya K.; Acharya, Ramesh P.; Huzdar, Shankar P.; Rimal, Nirmal; Myint, Khin S.; Gould, Philip

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Influenza A (H3N2) Outbreak, Nepal

Published Date:

Aug 2005

Source:

Emerg Infect Dis. 11(8):1186-1191.

[PDF-331.77 KB]

Details:

Personal Authors:

Daum, Luke T. ; Shaw, Michael W. ; Klimov, Alexander I. ; Canas, Linda C. ; Macias, Elizabeth A. ; ... More ▼

Keywords:

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Description:

In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that approximately 40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005-2006 influenza season. Thus, the 2005-2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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