Subclinical Markers of Cardiovascular Disease Among Police Officers: A Longitudinal Assessment of the Cortisol Awakening Response and Flow Mediated Artery Dilation

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Violanti, John M. ; Fekedulegn, Desta ; Andrew, Michael E. ; Charles, Luenda E. ; Gu, Ja K. ; Miller, Diane B.
• Description:
  Objective:
  
  To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a seven-year period.
  
  Methods:
  
  Baseline CAR was obtained from four saliva samples taken fifteen minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD%Follow-up-FMD%Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend.
  
  Results:
  
  Officers (n=172; 81% men) had a mean±SD age of 41±7.6 years. Men in the lowest AUCI tertile (i.e., atypical waking cortisol pattern) had a significantly larger seven-year mean decline in FMD% (mean±SE: −2.56±0.64) compared to men in the highest tertile (−0.89±0.69) (p=0.0087).
  
  Conclusion:
  
  An awakening cortisol AUCI predicted worsening of FMD% approximately seven years later among male officers.
  
  
• Subjects:
  Article Awakening Cortisol Brachial Reactivity Cardiovascular Disease Flow-mediated Dilation Police Stress
• Source:
  J Occup Environ Med. 60(9):853-859
• Pubmed ID:
  29787400
• Pubmed Central ID:
  PMC6380888
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/Intramural CDC HHS/United States ; R01 OH010807/NIOSH CDC HHS/National Institute for Occupational Safety and Health/United States
• Volume:
  60
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b33dcd5b7b60c4a176bba5a8bb931f9e282b207980bcd330cea69b4478df33bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/76038/cdc_76038_DS1.pdf
• File Type:
  [PDF - 144.26 KB ]