Vascular Responses to Long- and Short-Term Exposure to Fine Particulate Matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution)

Details

• Personal Author:
  Adar SD ; Barr RG ; Herrington DM ; Jorgensen NW ; Kaufman JD ; Krishnan RM ; O'Neill MS ; Polak JF ; Szpiro AA ; Van Hee VC
• Description:
  Objectives: This study evaluated the association of long- and short-term air pollutant exposures with flow-mediated dilation (FMD) and baseline arterial diameter (BAD) of the brachial artery using ultrasound in a large multicity cohort. Background: Exposures to ambient air pollution, especially long-term exposure to particulate matter <2.5 um in aerodynamic diameter (PM2.5), are linked with cardiovascular mortality. Short-term exposure to PM2.5 has been associated with decreased FMD and vasoconstriction, suggesting that adverse effects of PM2.5 may involve endothelial dysfunction. However, long-term effects of PM2.5 on endothelial dysfunction have not been investigated. Methods: FMD and BAD were measured by brachial artery ultrasound at the initial examination of the Multi-Ethnic Study of Atherosclerosis. Long-term PM2.5 concentrations were estimated for the year 2000 at each participant's residence (n = 3,040) using a spatio-temporal model informed by cohort-specific monitoring. Short-term PM2.5 concentrations were based on daily central-site monitoring in each of the 6 cities. Results: An interquartile increase in long-term PM2.5 concentration (3 ug/m3) was associated with a 0.3% decrease in FMD (95% confidence interval [CI] of difference: -0.6 to -0.03; p = 0.03), adjusting for demographic characteristics, traditional risk factors, sonographers, and 1/BAD. Women, nonsmokers, younger participants, and those with hypertension seemed to show a greater association of PM2.5 with FMD. FMD was not significantly associated with short-term variation in PM2.5 (-0.1% per 12 ug/m3 daily increase [95% CI: -0.2 to 0.04] on the day before examination). Conclusions: Long-term PM2.5 exposure was significantly associated with decreased endothelial function according to brachial ultrasound results. These findings may elucidate an important pathway linking air pollution and cardiovascular mortality. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Mortality Occupational Health Respiratory System Safety
• Keywords:
  Air Pollution Atherosclerosis Author Keywords: Air Pollution Cardiovascular Disease Cardiovascular Mortality Endothelial Function Environmental Health Flow-mediated Dilation Health Effects Mortality Rates Respiratory Function Traffic

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• ISSN:
  0735-1097
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  60
• Issue:
  21
• NIOSHTIC Number:
  nn:20054982
• Citation:
  J Am Coll Cardiol 2010 Nov; 60(21):2158-2166
• Contact Point Address:
  Dr. Ranjini M. Krishnan, University of Washington, Box Number 354695, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105
• Email:
  ranjik@u.washington.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of the American College of Cardiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eedc7023f9576fc89c871ffbb75c0d33469506f1a5025783ffb2f2166ebc4ade759f33511a39fb8946364dbb26c6c49cf7dcc59039e71ce61fb9185294d85f5b
• Download URL:
  https://stacks.cdc.gov/view/cdc/217388/cdc_217388_DS1.pdf
• File Type:
  [PDF - 724.11 KB ]