Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: A case-control study

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Park, Hyo K. ; Schildkraut, Joellen M. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa ; Crankshaw, Sydnee ; Funkhouser, Ellen ; Moorman, Patricia G. ; Peters, Edward S. ; Terry, Paul ; Wang, Frances ; Ruterbusch, Julie ; Schwartz, Ann G. ; Cote, Michele L.
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• Description:
  Background ; The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women. ; Methods ; Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer. ; Results ; 600 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between December 1, 2010 and December 31, 2015 comprised the study population. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.78; 95% CI 1.09–2.90). A non-significant association of similar magnitude was observed with PID (OR 1.33; 95% CI 0.82–2.16), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p=0.006) with consistency across histologic subtypes and among both oral contraceptive users and non-users. ; Conclusion ; A self-reported history of endometriosis among African-American women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions also increased ovarian cancer risk.
• Keywords:
  • ovarian cancer
  • African-American
  • endometriosis
  • pelvic inflammatory disease (PID)
  • ovarian cyst
  • uterine fibroid
  • African-American Cancer Epidemiology Study (AACES)
  • Adult
  • Black or African American
  • Aged
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• Source:
  Cancer Causes Control. 29(11):1081-1091
• Pubmed ID:
  30269307
• Pubmed Central ID:
  PMC6230481
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; R01CA142081/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; P30 CA022453/CA/NCI NIH HHSUnited States/ ; R01 CA142081/CA/NCI NIH HHSUnited States/ ; HHSN261201000028C/CA/NCI NIH HHSUnited States/
• Volume:
  29
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/60603/cdc_60603_DS1.pdf
• File Type:
  [PDF - 109.29 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e26076a534ba9e3656c6db974f05ab20f6e3050aa53bb3af50ae21d919b99870