Tubal ligation and ovarian cancer risk in African American women

McNamara, Chrissy; Abbott, Sarah E.; Bandera, Elisa V.; Qin, Bo; Peres, Lauren C.; Camacho, Fabian; Moorman, Patricia G.; Alberg, Anthony J.; Barnholtz-Sloan, Jill S.; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Schildkraut, Joellen M.; Terry, Paul

doi:10.1007/s10552-017-0943-6

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Tubal ligation and ovarian cancer risk in African American women

10 2017
By McNamara, Chrissy ; Abbott, Sarah E. ; Bandera, Elisa V. ; ...
http://dx.doi.org/10.1007/s10552-017-0943-6
Source: Cancer Causes Control. 28(10):1033-1041

[PDF-350.80 KB]

English

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Details:

Alternative Title:

Cancer Causes Control
Personal Author:

McNamara, Chrissy ; Abbott, Sarah E. ; Bandera, Elisa V. ; Qin, Bo ; Peres, Lauren C. ; ... More +

McNamara, Chrissy ; Abbott, Sarah E. ; Bandera, Elisa V. ; Qin, Bo ; Peres, Lauren C. ; Camacho, Fabian ; Moorman, Patricia G. ; Alberg, Anthony J. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Schildkraut, Joellen M. ; Terry, Paul Less -
Description:

Purpose

Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case–control study in 11 geographical areas in the US.

Methods

Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors.

Results

An inverse association between tubal ligation and EOC was observed that was not statistically significant (OR 0.88, 95% CI 0.68–1.14). However, an inverse association with EOC risk was observed among women who had a tubal ligation at age 35 years or older (OR 0.64; 95% CI 0.41–0.98), but not among those who had a tubal ligation before age 35 (OR 0.98; 95% CI 0.74–1.29) (p for interaction = 0.08). The association also varied considerably by tumor subtype. A strong inverse association was observed for endometrioid tumors (OR 0.31, 95% CI 0.14–0.70), whereas associations with mucinous (OR 0.87, 95% CI 0.36–2.12) and serous (OR 0.94, 95% CI 0.71–1.24) tumors were weaker and not statistically significant. A statistically non-significant positive association for clear cell tumors (OR 1.84, 95% CI 0.58–5.82) was based on a low number of cases.

Conclusions

Our findings show that tubal ligation may confer a reduced risk for EOC among AA women that is comparable to the associations that have been previously observed in primarily white populations.
Subjects:

[+]

Adult Aged Black Or African American Case-Control Studies Female Humans Logistic Models Middle Aged Odds Ratio Ovarian Neoplasms Risk Factors Sterilization, Tubal Young Adult
Keywords:

[+]

African-American Women Epidemiologic Studies Ovarian Cancer Tubal Ligation
Source:

Cancer Causes Control. 28(10):1033-1041
Pubmed ID:

28871344
Pubmed Central ID:

PMC6785827
Document Type:

Journal Article
Funding:

U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA072720/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; P30 CA022453/CA/NCI NIH HHSUnited States/ ; 1 R01 CA142081-01A1/National Cancer Institute/ ; ... More +

U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA072720/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; P30 CA022453/CA/NCI NIH HHSUnited States/ ; 1 R01 CA142081-01A1/National Cancer Institute/ ; R01 CA142081/CA/NCI NIH HHSUnited States/ ; HHSN261201000028C/CA/NCI NIH HHSUnited States/ Less -
Place as Subject:

United States
Volume:

28
Issue:

10
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:3a931368b0c861664f013a6aad86efdd247e4eae7cfe2e64ce7925ae175c5946
Download URL:

https://stacks.cdc.gov/view/cdc/154563/cdc_154563_DS1.pdf
File Type:

	nihms-1000551.nxml	xml
	NIHMS1000551-supplement-Supplemental_file.docx	docx

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