A swimming pool-associated outbreak of pharyngoconjunctival fever caused by human adenovirus type 4 in Beijing, China

Details

• Alternative Title:
  Int J Infect Dis
• Personal Author:
  Li, Jie ; Lu, Xiaoyan ; Sun, Yamin ; Lin, Changying ; Li, Feng ; Yang, Yang ; Liang, Zhichao ; Jia, Lei ; Chen, Lijuan ; Jiang, Baoming ; Wang, Quanyi
• Description:
  Patients with swimming pool-acquired human adenovirus (HAdV) infections usually manifest characteristic clinical features that include fever, pharyngitis, and conjunctival inflammation, syndromically referred to as pharyngoconjunctival fever (PCF). HAdV types 3, 4, and 7 are most commonly associated with PCF. This article reports an outbreak of PCF that involved 55 students and staff at a university in Beijing, China. Fifty patients had used the same swimming pool 2 weeks before the onset of symptoms. HAdV type 4 was identified from patient eye and throat swabs and concentrated swimming pool water samples. Partial hexon gene sequences obtained from the water samples were 100% identical to the sequences obtained from the swab samples, which clustered with HAdV-4 within species E. Swimming pool water contaminated with HAdV-4 was the most likely source of infection, although one instance of likely person-to-person transmission was noted.
• Subjects:
  Adenoviruses, Human Adenovirus Infections, Human Adult Aged China Disease Outbreaks Female Fresh Water Humans Male Middle Aged Swimming Pools Universities Young Adult

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• Keywords:
  Human Adenovirus Outbreak Pharyngoconjunctival Fever
• Source:
  Int J Infect Dis. 75:89-91
• Pubmed ID:
  30144556
• Pubmed Central ID:
  PMC6198331
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  75
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a7dcbab1e03feb558cecf1466e20d3dfa8befe6825cd29f5f1b5da1fcd322d5c
• Download URL:
  https://stacks.cdc.gov/view/cdc/60035/cdc_60035_DS1.pdf
• File Type:
  [PDF - 49.23 KB ]