Human Pegivirus in Patients with Encephalitis of Unclear Etiology, Poland

Bukowska-Ośko, Iwona; Perlejewski, Karol; Pawełczyk, Agnieszka; Rydzanicz, Małgorzata; Pollak, Agnieszka; Popiel, Marta; Cortés, Kamila Caraballo; Paciorek, Marcin; Horban, Andrzej; Dzieciątkowski, Tomasz; Radkowski, Marek; Laskus, Tomasz

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Human Pegivirus in Patients with Encephalitis of Unclear Etiology, Poland

Supporting Files Public Domain

Oct 2018
By Bukowska-Ośko, Iwona ; Perlejewski, Karol ; Pawełczyk, Agnieszka ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bukowska-Ośko, Iwona ; Perlejewski, Karol ; Pawełczyk, Agnieszka ; Rydzanicz, Małgorzata ; Pollak, Agnieszka ; Popiel, Marta ; Cortés, Kamila Caraballo ; Paciorek, Marcin ; Horban, Andrzej ; Dzieciątkowski, Tomasz ; Radkowski, Marek ; Laskus, Tomasz
Description:

Human pegivirus (HPgV), previously called hepatitis G virus or GB virus C, is a lymphotropic virus with undefined pathology. Because many viruses from the family Flaviviridae, to which HPgV belongs, are neurotropic, we studied whether HPgV could infect the central nervous system. We tested serum and cerebrospinal fluid samples from 96 patients with a diagnosis of encephalitis for a variety of pathogens by molecular methods and serology; we also tested for autoantibodies against neuronal antigens. We found HPgV in serum and cerebrospinal fluid from 3 patients who had encephalitis of unclear origin; that is, all the markers that had been tested were negative. Single-strand confirmation polymorphism and next-generation sequencing analysis revealed differences between the serum and cerebrospinal fluid-derived viral sequences, which is compatible with the presence of a separate HPgV compartment in the central nervous system. It is unclear whether HPgV was directly responsible for encephalitis in these patients.
Subjects:

Compartmentalization Encephalitis GB Virus C Hepatitis Human Pegivirus Human Pegivirus In Patients With Encephalitis Of Unclear Etiology, Poland Pegivirus Synopsis Viruses
Source:

Emerg Infect Dis. 24(10):1785-1794.
Pubmed ID:

30226156
Pubmed Central ID:

PMC6154136
Document Type:

Journal Article
Place as Subject:

Poland
Location:

Europe
Volume:

24
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:cf0787b23fff8282cb72a9830c102d084c8fbc14b06931d30a2525a400fe9218
Download URL:

https://stacks.cdc.gov/view/cdc/59459/cdc_59459_DS1.pdf
File Type:

[PDF - 2.84 MB ]

File Language:

English

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