Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection

Coller, Kelly E.; Bruce, Veronica; Cassidy, Michael; Gersch, Jeffrey; Frankel, Matthew B.; Vallari, Ana; Cloherty, Gavin; Hackett, John; Evans, Jennifer L.; Page, Kimberly; Dawson, George J.

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Chronic Human Pegivirus 2 without Hepatitis C Virus Co-infection

Feb 2020
By Coller, Kelly E. ; Bruce, Veronica ; Cassidy, Michael ; ...
Source: Emerg Infect Dis. 26(2):265-272

[PDF-563.61 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Coller, Kelly E. ; Bruce, Veronica ; Cassidy, Michael ; Gersch, Jeffrey ; Frankel, Matthew B. ; ... More +

Coller, Kelly E. ; Bruce, Veronica ; Cassidy, Michael ; Gersch, Jeffrey ; Frankel, Matthew B. ; Vallari, Ana ; Cloherty, Gavin ; Hackett, John ; Evans, Jennifer L. ; Page, Kimberly ; Dawson, George J. Less -
Description:

Most human pegivirus 2 (HPgV-2) infections are associated with past or current hepatitis C virus (HCV) infection. HPgV-2 is thought to be a bloodborne virus: higher prevalence of active infection has been found in populations with a history of parenteral exposure to viruses. We evaluated longitudinally collected blood samples obtained from injection drug users (IDUs) for active and resolved HPgV-2 infections using a combination of HPgV-2-specific molecular and serologic tests. We found evidence of HPgV-2 infection in 11.2% (22/197) of past or current HCV-infected IDUs, compared with 1.9% (4/205) of an HCV-negative IDU population. Testing of available longitudinal blood samples from HPgV-2-positive participants identified 5 with chronic infection (>6 months viremia in >3 timepoints); 2 were identified among the HCV-positive IDUs and 3 among the HCV-negative IDUs. Our findings indicate that HPgV-2 can establish chronic infection and replicate in the absence of HCV.
Subjects:

[+]

Bloodborne Pathogens Chronic Human Pegivirus 2 Without Hepatitis C Virus Co-infection Co-infection Hepatitis C Hepatitis Virus HPgV-2 Human Pegivirus 2 Intravenous Drug Use Pegivirus Prevalence Research Serologic Test Substance Abuse Viruses
Source:

Emerg Infect Dis. 26(2):265-272
Pubmed ID:

31961294
Pubmed Central ID:

PMC6986836
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:434e5273bb95c013833a4686e03bc09bbb62dc64ebb0a8c66d3e795cb5524f73
Download URL:

https://stacks.cdc.gov/view/cdc/84822/cdc_84822_DS1.pdf
File Type:

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	19-0434-F.jpg	jpeg
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