Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kaarme, Johan ; Riedel, Hilde ; Schaal, Wesley ; Yin, Hong ; Nevéus, Tryggve ; Melhus, Åsa
• Description:
  By collecting and analyzing diapers, we identified a >6-fold increase in carriage of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae for healthy preschool children in Sweden (p<0.0001). For 6 of the 50 participating preschools, the carriage rate was >40%. We analyzed samples from 334 children and found 56 containing >1 ESBL producer. The prevalence in the study population increased from 2.6% in 2010 to 16.8% in 2016 (p<0.0001), and for 6 of the 50 participating preschools, the carriage rate was >40%. Furthermore, 58% of the ESBL producers were multidrug resistant, and transmission of ESBL-producing and non-ESBL-producing strains was observed at several of the preschools. Toddlers appear to be major carriers of ESBL producers in Sweden.
• Subjects:
  AmpC Antimicrobial Resistance Bacteria Carriage Rates Cephalosporin Resistance Enteric Infections Enterobacteriaceae ESBLs Extended-spectrum β-lactamases Healthy Preschool Children Preschool Children Rapid Increase In Carriage Rates Of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases In Healthy Preschool Children, Sweden Research Respiratory Infections Whole-genome Sequencing

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• Source:
  Emerg Infect Dis. 24(10):1874-1881.
• Pubmed ID:
  30226162
• Pubmed Central ID:
  PMC6154144
• Document Type:
  Journal Article
• Place as Subject:
  Sweden
• Location:
  Europe
• Volume:
  24
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7755a42feb2c7961d6138c38c25d88447597f6bc494aa21e7ae16a24311014e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/59448/cdc_59448_DS1.pdf
• File Type:
  [PDF - 1.14 MB ]