Incidence of primary liver cancer in American Indians and Alaska Natives, US, 1999–2009

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Melkonian, Stephanie C. ; Jim, Melissa A. ; Reilley, Brigg ; Erdrich, Jennifer ; Berkowitz, Zahava ; Wiggins, Charles L. ; Haverkamp, Donald ; White, Mary C.
• Description:
  Purpose
  
  To evaluate liver cancer incidence rates and risk factor correlations in non-Hispanic AI/AN populations for the years 1999–2009.
  
  Methods
  
  We linked data from 51 central cancer registries with the Indian Health Service patient registration databases to improve identification of the AI/AN population. Analyses were restricted to non-Hispanic persons living in Contract Health Service Delivery Area counties. We compared age-adjusted liver cancer incidence rates (per 100,000) for AI/AN to white populations using rate ratios. Annual percent changes (APCs) and trends were estimated using joinpoint regression analyses. We evaluated correlations between regional liver cancer incidence rates and risk factors using Pearson correlation coefficients.
  
  Results
  
  AI/AN persons had higher liver cancer incidence rates than whites overall (11.5 versus 4.8, RR = 2.4, 95% CI 2.3– 2.6). Rate ratios ranged from 1.6 (Southwest) to 3.4 (Northern Plains and Alaska). We observed an increasing trend among AI/AN persons (APC 1999–2009 = 5%). Rates of distant disease were higher in the AI/AN versus white population for all regions except Alaska. Alcohol use (r = 0.84) and obesity (r = 0.79) were correlated with liver cancer incidence by region.
  
  Conclusions
  
  Findings highlight disparities in liver cancer incidence between AI/AN and white populations and emphasize opportunities to decrease liver cancer risk factor prevalence.
  
  
• Subjects:
  Adenocarcinoma Adult Aged Alaska Natives Female Humans Incidence Indians, North American Liver Neoplasms Male Middle Aged Registries Risk Factors

  More +
• Source:
  Cancer Causes Control. 29(9):833-844
• Pubmed ID:
  30030669
• Pubmed Central ID:
  PMC6108913
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  29
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6eacceea705b4a7091f2888b5a9aa60751fec76fc4305820426c862e5871bc94
• Download URL:
  https://stacks.cdc.gov/view/cdc/58379/cdc_58379_DS1.pdf
• File Type:
  [PDF - 364.41 KB ]