Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients

Rafat, Marjan; Aguilera, Todd A.; Vilalta, Marta; Bronsart, Laura L.; Soto, Luis A.; von Eyben, Rie; Golla, Meghana A.; Ahrari, Yasaman; Melemenidis, Stavros; Afghahi, Anosheh; Jenkins, Melissa J.; Kurian, Allison W.; Horst, Kathleen C.; Giaccia, Amato J.; Graves, Edward E.

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Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients

Published Date:

June 07 2018

Source:

Cancer Res. 78(15):4241-4252

Language:

English

[PDF-1.34 MB]

Details:

Personal Authors:

Rafat, Marjan ; Aguilera, Todd A. ; Vilalta, Marta ; Bronsart, Laura L. ; Soto, Luis A. ; ... More ▼

Keywords:

[+]

Pubmed ID:

29880480

Pubmed Central ID:

PMC6072588

Description:

Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis that recurrence in some instances is due to the attraction of circulating tumor cells to irradiated tissues. To evaluate the effect of absolute lymphocyte count on local recurrence after RT in patients with TNBC, we analyzed radiation effects on tumor and immune cell recruitment to tissues in an orthotopic breast cancer model. Recurrent patients exhibited a prolonged low absolute lymphocyte count when compared with nonrecurrent patients following RT. Recruitment of tumor cells to irradiated normal tissues was enhanced in the absence of CD8| T cells. Macrophages (CD11b|F480|) preceded tumor cell infiltration and were recruited to tissues following RT. Tumor cell recruitment was mitigated by inhibiting macrophage infiltration using maraviroc, an FDA-approved CCR5 receptor antagonist. Our work poses the intriguing possibility that excessive macrophage infiltration in the absence of lymphocytes promotes local recurrence after RT. This combination thus defines a high-risk group of patients with TNBC.| This study establishes the importance of macrophages in driving tumor cell recruitment to sites of local radiation therapy and suggests that this mechanism contributes to local recurrence in women with TNBC that are also immunosuppressed.| http://cancerres.aacrjournals.org/content/canres/78/15/4241/F1.large.jpg |.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

S10 OD018208/OD/NIH HHS/United States
HHSN261201000140C/CA/NCI NIH HHS/United States
K99 CA201304/CA/NCI NIH HHS/United States
P01 CA067166/CA/NCI NIH HHS/United States
HHSN261201000035C/CA/NCI NIH HHS/United States
T32 CA121940/CA/NCI NIH HHS/United States
R01 CA197136/CA/NCI NIH HHS/United States
U58 DP000807/DP/NCCDPHP CDC HHS/United States
HHSN261201000035I/CA/NCI NIH HHS/United States
UL1 RR025744/RR/NCRR NIH HHS/United States
HHSN261201000034C/CA/NCI NIH HHS/United States

Main Document Checksum:

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Supporting Files:

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