Frequent Implication of Multistress-Tolerant Campylobacter jejuni in Human Infections

Oh, Euna; Chui, Linda; Bae, Junghee; Li, Vincent; Ma, Angela; Mutschall, Steven K.; Taboada, Eduardo N.; McMullen, Lynn M.; Jeon, Byeonghwa

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Frequent Implication of Multistress-Tolerant Campylobacter jejuni in Human Infections

Supporting Files Public Domain

Jun 2018
By Oh, Euna ; Chui, Linda ; Bae, Junghee ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Oh, Euna ; Chui, Linda ; Bae, Junghee ; Li, Vincent ; Ma, Angela ; Mutschall, Steven K. ; Taboada, Eduardo N. ; McMullen, Lynn M. ; Jeon, Byeonghwa
Description:

Campylobacter jejuni, a major cause of bacterial foodborne illnesses, is considered highly susceptible to environmental stresses. In this study, we extensively investigated the stress tolerance of 121 clinical strains of C. jejuni against 5 stress conditions (aerobic stress, disinfectant exposure, freeze-thaw, heat treatment, and osmotic stress) that this pathogenic bacterium might encounter during foodborne transmission to humans. In contrast to our current perception about high stress sensitivity of C. jejuni, a number of clinical strains of C. jejuni were highly tolerant to multiple stresses. We performed population genetics analysis by using comparative genomic fingerprinting and showed that multistress-tolerant strains of C. jejuni constituted distinct clades. The comparative genomic fingerprinting subtypes belonging to multistress-tolerant clades were more frequently implicated in human infections than those in stress-sensitive clades. We identified unique stress-tolerant C. jejuni clones and showed the role of stress tolerance in human campylobacteriosis.
Subjects:

Adaptation, Biological Animals Campylobacter Infections Campylobacter Jejuni Chickens Environmental Microbiology Foodborne Diseases Food Microbiology Humans Microbial Viability Osmolar Concentration Stress, Physiological Temperature
Source:

Emerg Infect Dis. 24(6):1037-1044.
Pubmed ID:

29774830
Pubmed Central ID:

PMC6004869
Document Type:

Journal Article
Place as Subject:

Alberta, Canada
Volume:

24
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:780821bf29e38dfb658714926da99f7b9c0402f675a68c0aab8f44ee3caa37c1
Download URL:

https://stacks.cdc.gov/view/cdc/56317/cdc_56317_DS1.pdf
File Type:

[PDF - 2.50 MB ]

File Language:

English

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