The Importance of the Circadian System & Sleep for Bone Health

Details

• Alternative Title:
  Metabolism
• Personal Author:
  Swanson, Christine M. ; Kohrt, Wendy M. ; Buxton, Orfeu M. ; Everson, Carol A. ; Wright, Kenneth P. ; Orwoll, Eric S. ; Shea, Steven A.
• Description:
  Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.
• Subjects:
  Animals Bone And Bones Bone Density Circadian Clocks Circadian Rhythm Health Humans Sleep Sleep Deprivation
• Keywords:
  Bone Bone Turnover Circadian Fracture Sleep
• Source:
  Metabolism. 84:28-43
• Pubmed ID:
  29229227
• Pubmed Central ID:
  PMC5994176
• Document Type:
  Journal Article
• Funding:
  R01 HL125893/HL/NHLBI NIH HHSUnited States/ ; R01 HL131458/HL/NHLBI NIH HHSUnited States/ ; UL1 TR000128/TR/NCATS NIH HHSUnited States/ ; R01 HL135598/HL/NHLBI NIH HHSUnited States/ ; U01 AG042145/AG/NIA NIH HHSUnited States/ ; U01 AG042168/AG/NIA NIH HHSUnited States/ ; U01 HL111478/HL/NHLBI NIH HHSUnited States/ ; R01 HL132150/HL/NHLBI NIH HHSUnited States/ ; U01 AG027810/AG/NIA NIH HHSUnited States/ ; U01 AG042143/AG/NIA NIH HHSUnited States/ ; U01 AG042139/AG/NIA NIH HHSUnited States/ ; U01 AR066160/AR/NIAMS NIH HHSUnited States/ ; R01 HL118601/HL/NHLBI NIH HHSUnited States/ ; P30 DK048520/DK/NIDDK NIH HHSUnited States/ ; R01 HD087707/HD/NICHD NIH HHSUnited States/ ; UL1 TR002369/TR/NCATS NIH HHSUnited States/ ; U01 AG042124/AG/NIA NIH HHSUnited States/ ; R43 AG056250/AG/NIA NIH HHSUnited States/ ; R01 HL140577/HL/NHLBI NIH HHSUnited States/ ; K23 AR070275/AR/NIAMS NIH HHSUnited States/ ; U01 AG042140/AG/NIA NIH HHSUnited States/ ; P01 AG009975/AG/NIA NIH HHSUnited States/
• Volume:
  84
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b74885ae2126c5a87e1dfce912b4a052c3f50c13136f4bcec021631c1d4bf698
• Download URL:
  https://stacks.cdc.gov/view/cdc/55840/cdc_55840_DS1.pdf
• File Type:
  [PDF - 659.31 KB ]