The Importance of the Circadian System & Sleep for Bone Health

Details

• Personal Author:
  Buxton OM ; Everson CA ; Kohrt WM ; Orwoll ES ; Shea SA ; Swanson CM ; Wright KP Jr.
• Description:
  Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health. [Description provided by NIOSH]
• Subjects:
  Biomarkers Circadian Rhythm Occupational Health Safety Sleep
• Keywords:
  Author Keywords: Sleep Biological Effects Bone Fracture Bone Structure Bone Turnover Circadian Circadian Rhythms Shift Workers Total Worker Health TWH
• ISSN:
  0026-0495
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Massachusetts ; Oregon ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 8 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28-43
• Volume:
  84
• NIOSHTIC Number:
  nn:20053911
• Citation:
  Metab Clin Exp 2018 Jul; 84:28-43
• Contact Point Address:
  Christine M. Swanson, 12801 E. 17th Ave. Mail Stop 8106, Aurora, CO 80045, USA
• Email:
  Christine.Swanson@UCDenver.edu
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Services ; Transportation, Warehousing and Utilities
• Performing Organization:
  Oregon Health & Science University, Portland
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Metabolism: Clinical and Experimental
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:98389128ef3184012eaecc4431ba40c30a737da684ae0f8f2f47ccb13523828b4385c841ad73be0a8374c23199075331a2cb414aaf41e9d4d155903fa0ddc650
• Download URL:
  https://stacks.cdc.gov/view/cdc/216581/cdc_216581_DS1.pdf
• File Type:
  [PDF - 500.95 KB ]