Sleep Restriction with Circadian Disruption Negatively Alter Bone Turnover Markers in Women

Details

• Personal Author:
  Buxton OM ; Cain SW ; Czeisler, Charles A. ; Kohrt WM ; Munch M ; Orwoll ES ; Shea SA ; Swanson CM ; Vujovic N ; Wright KP Jr.
• Description:
  Purpose: The purpose of this work is to determine whether an uncoupling of bone turnover markers (BTMs) occurs in women exposed to the combination of sleep restriction with circadian disruption (SRCD), as previously reported in men. Methods: Four bone biomarkers (N-terminal propeptide of type I procollagen [P1NP] and osteocalcin = bone formation; C-telopeptide [CTX] = bone resorption; sclerostin = bone formation inhibitor) were measured in bihourly samples over 24 hours at baseline and after approximately 3 weeks of sleep restriction (approx. 5.6 hours of sleep/24 hours) with concurrent circadian disruption (SRCD, recurring 28-hour "day" in dim light). Maximum likelihood estimation in a repeated-measures model was used to assess the effects of SRCD and age on bone biomarkers. Results: Five women were young (22 +/- 2.8 years) and four were older (58 +/- 1.8 years). Baseline bone biomarker levels did not differ by age (all P >/= .07). Bone formation markers were lower after SRCD (estimate +/- SEE, delta P1NP = -9.5 +/- 2.8 ug/L, P = .01; delta osteocalcin = -2.3 +/- 0.9 ng/mL, P = .04). The P1NP decline was greater in young women (delta P1NP = -12.9 +/- 3.7 ug/L, P = .01). After SRCD, CTX was significantly higher in young women (0.182 +/- 0.069 ng/mL, P = .04) but did not change in older women. Conclusions: These pilot data are similar to previous findings in men and suggest that SRCD negatively altered bone metabolism in women by decreasing markers of bone formation and, in young women, increasing a marker of bone resorption. If sustained, this pattern of BTM uncoupling may lead to bone loss and lower bone mineral density. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Circadian Rhythm Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders Women
• Keywords:
  Age Factors Author Keywords: Sleep Bone Disorders Bone Turnover Markers Circadian Disruption Circadian Rhythms CTX P1NP Shift Work Sleep Deprivation Total Worker Health TWH

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• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Massachusetts ; Oregon ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 8 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  105
• Issue:
  7
• NIOSHTIC Number:
  nn:20061633
• Citation:
  J Clin Endocrinol Metab 2020 Jul; 105(7):2456-2463
• Contact Point Address:
  Christine M. Swanson, MD, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Mail Stop 8106, Aurora, CO 80045
• Email:
  Christine.Swanson@CUAnschutz.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Services ; Transportation, Warehousing and Utilities
• Performing Organization:
  Oregon Health & Science University, Portland
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f35dfb9082db5323004f278cc1cee40d021330c04e5313efb84472f94bfc3b15538d4ca8f15e0d43f7b634b735724ac5cdd09fb72d7f16c611162d66917e06cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/225097/cdc_225097_DS1.pdf
• File Type:
  [PDF - 232.88 KB ]