Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam

Anh, Nguyen To; Nhu, Le Nguyen Truc; Van, Hoang Minh Tu; Hong, Nguyen Thi Thu; Thanh, Tran Tan; Hang, Vu Thi Ty; Ny, Nguyen Thi Han; Nguyet, Lam Anh; Phuong, Tran Thi Lan; Nhan, Le Nguyen Thanh; Hung, Nguyen Thanh; Khanh, Truong Huu; Tuan, Ha Manh; Viet, Ho Lu; Nam, Nguyen Tran; Viet, Do Chau; Qui, Phan Tu; Wills, Bridget; Sabanathan, Sarawathy; Chau, Nguyen Van Vinh; Thwaites, Louise; Rogier van Doorn, H.; Thwaites, Guy; Rabaa, Maia A.; Van Tan, Le

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Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam

Supporting Files Public Domain

Apr 2018
By Anh, Nguyen To ; Nhu, Le Nguyen Truc ; Van, Hoang Minh Tu ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Anh, Nguyen To ; Nhu, Le Nguyen Truc ; Van, Hoang Minh Tu ; Hong, Nguyen Thi Thu ; Thanh, Tran Tan ; Hang, Vu Thi Ty ; Ny, Nguyen Thi Han ; Nguyet, Lam Anh ; Phuong, Tran Thi Lan ; Nhan, Le Nguyen Thanh ; Hung, Nguyen Thanh ; Khanh, Truong Huu ; Tuan, Ha Manh ; Viet, Ho Lu ; Nam, Nguyen Tran ; Viet, Do Chau ; Qui, Phan Tu ; Wills, Bridget ; Sabanathan, Sarawathy ; Chau, Nguyen Van Vinh ; Thwaites, Louise ; Rogier van Doorn, H. ; Thwaites, Guy ; Rabaa, Maia A. ; Van Tan, Le
Description:

Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011-2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare. Skyline plots identified fluctuations in the relative genetic diversity of CV-A6 corresponding to large CV-A6-associated HFMD outbreaks worldwide. These data show that CV-A6 is an emerging pathogen and emphasize the necessity of active surveillance and understanding the mechanisms that shape the pathogen evolution and emergence, which is essential for development and implementation of intervention strategies.
Subjects:

Adult Child Communicable Diseases, Emerging Coxsackievirus Infections Enterovirus A, Human Female Genome, Viral Genomics Hand, Foot And Mouth Disease Humans Male Phylogeny Phylogeography Whole Genome Sequencing Young Adult
Source:

Emerg Infect Dis. 24(4):654-662.
Pubmed ID:

29553326
Pubmed Central ID:

PMC5875260
Document Type:

Journal Article
Place as Subject:

Vietnam
Volume:

24
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:b308de6a7b4e86968cf0defc48364df1ce73cc35c5bb8ae2d72e3a4207d6b703
Download URL:

https://stacks.cdc.gov/view/cdc/53056/cdc_53056_DS1.pdf
File Type:

[PDF - 2.67 MB ]

File Language:

English

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