Use of Verbal Autopsy to Determine Underlying Cause of Death during Treatment of Multidrug-Resistant Tuberculosis, India

Naik, Poonam Ramesh; Moonan, Patrick K.; Nirgude, Abhay Subhashrao; Shewade, Hemant Deepak; Satyanarayana, Srinath; Raghuveer, Pracheth; Parmar, Malik; Ravichandra, Chinnappareddy; Singarajipura, Anil

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Use of Verbal Autopsy to Determine Underlying Cause of Death during Treatment of Multidrug-Resistant Tuberculosis, India

Supporting Files Public Domain

Mar 2018
By Naik, Poonam Ramesh ; Moonan, Patrick K. ; Nirgude, Abhay Subhashrao ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Naik, Poonam Ramesh ; Moonan, Patrick K. ; Nirgude, Abhay Subhashrao ; Shewade, Hemant Deepak ; Satyanarayana, Srinath ; Raghuveer, Pracheth ; Parmar, Malik ; Ravichandra, Chinnappareddy ; Singarajipura, Anil
Description:

Of patients with multidrug-resistant tuberculosis (MDR TB), <50% complete treatment. Most treatment failures for patients with MDR TB are due to death during TB treatment. We sought to determine the proportion of deaths during MDR TB treatment attributable to TB itself. We used a structured verbal autopsy tool to interview family members of patients who died during MDR TB treatment in India during January-December 2016. A committee triangulated information from verbal autopsy, death certificate, or other medical records available with the family members to ascertain the underlying cause of death. For 66% of patient deaths (47/71), TB was the underlying cause of death. We assigned TB as the underlying cause of death for an additional 6 patients who died of suicide and 2 of pulmonary embolism. Deaths during TB treatment signify program failure; accurately determining the cause of death is the first step to designing appropriate, timely interventions to prevent premature deaths.
Subjects:

Adolescent Adult Aged Anti-Bacterial Agents Autopsy Cause Of Death Cross-Sectional Studies Drug Resistance, Multiple, Bacterial Female Geography Humans Male Middle Aged Mycobacterium Tuberculosis Research Tuberculosis, Multidrug-Resistant Young Adult
Source:

Emerg Infect Dis. 24(3):478-484.
Pubmed ID:

29460737
Pubmed Central ID:

PMC5823351
Document Type:

Journal Article
Place as Subject:

India
Location:

Asia
Volume:

24
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:920b04e94ce1c46ca86773162c19f745522acbea6b16470d20a96e0580f024dd
Download URL:

https://stacks.cdc.gov/view/cdc/52200/cdc_52200_DS1.pdf
File Type:

[PDF - 4.89 MB ]

File Language:

English

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