Details:

Alternative Title:
Int J Tuberc Lung Dis
Publisher's site:
http://dx.doi.org/10.5588/ijtld.18.0163
Personal Author:
Swindells, Susan ; Gupta, Amita ; Kim, Soyeon ; Hughes, Michael D. ; Sanchez, Jorge ; ... More +
Swindells, Susan ; Gupta, Amita ; Kim, Soyeon ; Hughes, Michael D. ; Sanchez, Jorge ; Mave, Vidya ; Dawson, Rodney ; Kumarasamy, Nagalingeswaran ; Comins, Kyla ; Smith, Betsy ; Rustomjee, Roxana ; Naini, Linda ; Shah, N. Sarita ; Hesseling, Anneke ; Churchyard, Gavin Less -
Description:
Background

Current guidelines recommend evaluation of household contacts (HHC) of individuals with multidrug-resistant tuberculosis (MDR-TB) but widespread implementation of this policy is challenging.

Objective

To describe site-level resource utilization and operational challenges encountered when identifying, recruiting, and characterizing adult MDR-TB Index Cases and their HHC.

Design

Cross-sectional study of adult MDR-TB Index Cases and HHC at 16 clinical research sites in 8 countries. Site-level resource utilization was assessed using structured surveys.

Results

Between October 2015 and April 2016, 308 Index Cases and 1018 HHC were enrolled. Of 280 Index Cases with sputum collected, 94 were smear positive (34%, 95% Confidence Interval (CI): 28–39%) and of 201 with chest x-rays, 87 had cavitary disease (43%, CI: 37–50%) after a mean duration of treatment of 8 weeks. Staff required 512 attempts to evaluate the 308 households, median time per attempt of 4 hours. 77% (CI: 73─80%) of the HHC were at increased risk for TB: 13% < 5 years; 8% >5 years. and HIV-infected; and 79% >5 years, HIV-/unknown and TST/IGRA positive. 121 previously undiagnosed TB cases were identified. Issues identified by site staff included complexity of personnel and participant transportation, infection control, personnel safety and management of stigma surrounding household visits.

Conclusion

Household contact investigations can be high yield but are labor intensive.


Keywords:
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Adolescent Adult Aged Contact Tracing Cross-Sectional Studies Family Characteristics Female Health Resources Household Contact Investigation Humans Interferon-gamma Release Tests Internationality Male MDR-TB Middle Aged Radiography, Thoracic Resource Utilization Sputum Tuberculin Test Tuberculosis, Multidrug-Resistant Young Adult
Source:
Int J Tuberc Lung Dis. 22(9):1016-1022
Pubmed ID:
30092866
Pubmed Central ID:
PMC6104641
Document Type:
Journal Article
Funding:
UM1 AI069476/AI/NIAID NIH HHSUnited States/ ; UM1 AI069456/AI/NIAID NIH HHSUnited States/ ; UM1 AI069421/AI/NIAID NIH HHSUnited States/ ; UM1 AI069438/AI/NIAID NIH HHSUnited States/ ; UM1 AI068632/AI/NIAID NIH HHSUnited States/ ; ... More +
UM1 AI069476/AI/NIAID NIH HHSUnited States/ ; UM1 AI069456/AI/NIAID NIH HHSUnited States/ ; UM1 AI069421/AI/NIAID NIH HHSUnited States/ ; UM1 AI069438/AI/NIAID NIH HHSUnited States/ ; UM1 AI068632/AI/NIAID NIH HHSUnited States/ ; U01 AI068616/AI/NIAID NIH HHSUnited States/ ; U01 AI068636/AI/NIAID NIH HHSUnited States/ ; U01 AI069521/AI/NIAID NIH HHSUnited States/ ; UM1 AI106701/AI/NIAID NIH HHSUnited States/ ; UM1 AI106716/AI/NIAID NIH HHSUnited States/ ; U01 AI069463/AI/NIAID NIH HHSUnited States/ ; UM1 AI069432/AI/NIAID NIH HHSUnited States/ ; HHSN275201300003C/HD/NICHD NIH HHSUnited States/ ; UM1 AI068634/AI/NIAID NIH HHSUnited States/ ; UM1 AI069453/AI/NIAID NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; UM1 AI069463/AI/NIAID NIH HHSUnited States/ ; UM1 AI068616/AI/NIAID NIH HHSUnited States/ ; UM1 AI069521/AI/NIAID NIH HHSUnited States/ ; UM1 AI069465/AI/NIAID NIH HHSUnited States/ ; UM1 AI068636/AI/NIAID NIH HHSUnited States/ ; UM1 AI069418/AI/NIAID NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1328f60401dc5e8330e69cebf9ba95818e3d71c76a93872122e1ef92863b9df2
Download URL:
https://stacks.cdc.gov/view/cdc/76886/cdc_76886_DS1.pdf
File Type:

Supporting Files

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