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Adenovirus Type 4 Respiratory Infections among Civilian Adults, Northeastern United States, 2011–20151
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Feb 2018
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Source: Emerg Infect Dis. 24(2):201-209.
[PDF-1.79 MB]
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Alternative Title:Emerg Infect Dis
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Description:Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases. Two novel a-like variants were recovered from students enrolled at a college in Tompkins County, New York, USA, and a prototype-like variant distinguishable from the vaccine strain was isolated from an 18-year-old woman visiting a physician's office in Ulster County, New York, USA, with symptoms of influenza-like illness. Our data suggest that HAdV-4 might be an underestimated causative agent of ARD among civilian adults.
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Pubmed ID:29350143
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Pubmed Central ID:PMC5782899
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Volume:24
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Issue:2
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