Genomic epidemiology reveals multiple introductions of Zika virus into the United States

Details

• Alternative Title:
  Nature
• Personal Author:
  Grubaugh, Nathan D ; Ladner, Jason T ; Kraemer, Moritz UG ; Dudas, Gytis ; Tan, Amanda L ; Gangavarapu, Karthik ; Wiley, Michael R ; White, Stephen ; Thézé, Julien ; Magnani, Diogo M ; Prieto, Karla ; Reyes, Daniel ; Bingham, Andrea ; Paul, Lauren M ; Robles-Sikisaka, Refugio ; Oliveira, Glenn ; Pronty, Darryl ; Barcellona, Carolyn M ; Metsky, Hayden C ; Baniecki, Mary Lynn ; Barnes, Kayla G ; Chak, Bridget ; Freije, Catherine A ; Gladden-Young, Adrianne ; Gnirke, Andreas ; Luo, Cynthia ; MacInnis, Bronwyn ; Matranga, Christian B ; Park, Daniel J ; Qu, James ; Schaffner, Stephen F ; Tomkins-Tinch, Christopher ; West, Kendra L ; Winnicki, Sarah M ; Wohl, Shirlee ; Yozwiak, Nathan L ; Quick, Joshua ; Fauver, Joseph R ; Khan, Kamran ; Brent, Shannon E ; Reiner, Robert C ; Lichtenberger, Paola N ; Ricciardi, Michael ; Bailey, Varian K ; Watkins, David I ; Cone, Marshall R ; Kopp, Edgar W ; Hogan, Kelly N ; Cannons, Andrew C ; Jean, Reynald ; Monaghan, Andrew J ; Garry, Robert F ; Loman, Nicholas J ; Faria, Nuno R ; Porcelli, Mario C ; Vasquez, Chalmers ; Nagle, Elyse R ; Cummings, Derek AT ; Stanek, Danielle ; Rambaut, Andrew ; Sanchez-Lockhart, Mariano ; Sabeti, Pardis C ; Gillis, Leah D ; Michael, Scott F ; Bedford, Trevor ; Pybus, Oliver G ; Isern, Sharon ; Palacios, Gustavo ; Andersen, Kristian G
• Description:
  Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
• Keywords:
  Aedes Animals Caribbean Region Disease Outbreaks Female Florida Genome, Viral Humans Incidence Molecular Epidemiology Mosquito Vectors Zika Virus Zika Virus Infection

  More +
• Source:
  Nature. 546(7658):401-405
• Pubmed ID:
  28538723
• Pubmed Central ID:
  PMC5536180
• Document Type:
  Journal Article
• Funding:
  U19 AI115589/AI/NIAID NIH HHSUnited States/ ; R01 AI099210/AI/NIAID NIH HHSUnited States/ ; MC_PC_15100/MRC_/Medical Research CouncilUnited Kingdom/ ; UL1 TR001114/TR/NCATS NIH HHSUnited States/ ; MR/L015080/1/MRC_/Medical Research CouncilUnited Kingdom/ ; R35 GM119774/GM/NIGMS NIH HHSUnited States/ ; U01CK000510/ACL/ACL HHSUnited States/ ; T32 AI007244/AI/NIAID NIH HHSUnited States/ ; UL1 TR000460/TR/NCATS NIH HHSUnited States/ ; U01 CK000510/CK/NCEZID CDC HHSUnited States/ ; 260864/ERC_/European Research CouncilInternational/ ; HHSN272201400048C/AI/NIAID NIH HHSUnited States/ ; S10 OD020069/OD/NIH HHSUnited States/ ; WT_/Wellcome TrustUnited Kingdom/ ; MR/M501621/1/MRC_/Medical Research CouncilUnited Kingdom/ ; U54 GM088491/GM/NIGMS NIH HHSUnited States/
• Volume:
  546
• Issue:
  7658
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e4ca7275efccd197a6aed3cd156ff08e9ca48b6f6217f2f745f42466a7cc48af
• Download URL:
  https://stacks.cdc.gov/view/cdc/47219/cdc_47219_DS1.pdf
• File Type:
  [PDF - 4.73 MB ]