Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus

Becker, Karsten; van Alen, Sarah; Idelevich, Evgeny A.; Schleimer, Nina; Seggewiß, Jochen; Mellmann, Alexander; Kaspar, Ursula; Peters, Georg

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Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus

Feb 2018
By Becker, Karsten ; van Alen, Sarah ; Idelevich, Evgeny A. ; ...
Source: Emerg Infect Dis. 24(2):242-248.

[PDF-1015.95 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Becker, Karsten ; van Alen, Sarah ; Idelevich, Evgeny A. ; Schleimer, Nina ; Seggewiß, Jochen ; ... More +

Becker, Karsten ; van Alen, Sarah ; Idelevich, Evgeny A. ; Schleimer, Nina ; Seggewiß, Jochen ; Mellmann, Alexander ; Kaspar, Ursula ; Peters, Georg Less -
Description:

During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by β-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmidborne β-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of β-lactams as a main therapeutic application against staphylococcal infections.
Subjects:

[+]

Aged Bacterial Proteins/genetics Gene Transfer, Horizontal Humans Male Methicillin Resistance Plasmids/genetics Research
Source:

Emerg Infect Dis. 24(2):242-248.
Pubmed ID:

29350135
Pubmed Central ID:

PMC5782906
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:5b47a7e88b0847e1fca862b75e146b33e098068484ba599043b40e3a81c79a8e
Download URL:

https://stacks.cdc.gov/view/cdc/51385/cdc_51385_DS1.pdf
File Type:

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	17-1074-F.jpg	jpeg
	17-1074-Techapp-s1.pdf	pdf
	17-1074.nxml	xml

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