Viruses Associated With Acute Respiratory Infections and Influenza-like Illness Among Outpatients From the Influenza Incidence Surveillance Project, 2010–2011

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Fowlkes, Ashley ; Giorgi, Andrea ; Erdman, Dean ; Temte, Jon ; Goodin, Kate ; Di Lonardo, Steve ; Sun, Yumei ; Martin, Karen ; Feist, Michelle ; Linz, Rachel ; Boulton, Rachelle ; Bancroft, Elizabeth ; McHugh, Lisa ; Lojo, Jose ; Filbert, Kimberly ; Finelli, Lyn
• Corporate Authors:
  for the IISP Working Group
• Description:
  Background
  
  The Influenza Incidence Surveillance Project (IISP) monitored outpatient acute respiratory infection (ARI; defined as the presence of ≥2 respiratory symptoms not meeting ILI criteria) and influenza-like illness (ILI) to determine the incidence and contribution of associated viral etiologies.
  
  Methods
  
  From August 2010 through July 2011, 57 outpatient healthcare providers in 12 US sites reported weekly the number of visits for ILI and ARI and collected respiratory specimens on a subset for viral testing. The incidence was estimated using the number of patients in the practice as the denominator, and the virus-specific incidence of clinic visits was extrapolated from the proportion of patients testing positive.
  
  Results
  
  The age-adjusted cumulative incidence of outpatient visits for ARI and ILI combined was 95/1000 persons, with a viral etiology identified in 58% of specimens. Most frequently detected were rhinoviruses/enteroviruses (RV/EV) (21%) and influenza viruses (21%); the resulting extrapolated incidence of outpatient visits was 20 and 19/1000 persons respectively. The incidence of influenza virus-associated clinic visits was highest among patients aged 2–17 years, whereas other viruses had varied patterns among age groups.
  
  Conclusions
  
  The IISP provides a unique opportunity to estimate the outpatient respiratory illness burden by etiology. Influenza virus infection and RV/EV infection(s) represent a substantial burden of respiratory disease in the US outpatient setting, particularly among children.
  
  
• Subjects:
  Acute Respiratory Illness Adolescent Adult Aged Article Child Child, Preschool Epidemiology Female Humans Incidence Infant Influenza Influenza, Human Influenza-like Illness Male Middle Aged Outpatients Population Surveillance Respiratory Tract Infections Respiratory Virus Reverse Transcriptase Polymerase Chain Reaction Seasonality United States Young Adult

  More +
• Source:
  J Infect Dis. 209(11):1715-1725
• Pubmed ID:
  24338352
• Pubmed Central ID:
  PMC5749912
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; U38 HM000414/HM/NCHM CDC HHS/United States ; 5U38HM000414-04/HM/NCHM CDC HHS/United States
• Volume:
  209
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d36e2bf30ffda9c38312d260a4b9ce4bb7c106f46af37c5a146022ffa15d9cd2
• Download URL:
  https://stacks.cdc.gov/view/cdc/50679/cdc_50679_DS1.pdf
• File Type:
  [PDF - 666.37 KB ]