Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

Raabe, Vanessa N.; Kann, Gerrit; Ribner, Bruce S.; Morales, Andres; Varkey, Jay B.; Mehta, Aneesh K.; Lyon, G. Marshall; Vanairsdale, Sharon; Faber, Kelly; Becker, Stephan; Eickmann, Markus; Strecker, Thomas; Brown, Shelley; Patel, Ketan; De Leuw, Philipp; Schuettfort, Gundolf; Stephan, Christoph; Rabenau, Holger; Klena, John D.; Rollin, Pierre E.; McElroy, Anita; Ströher, Ute; Nichol, Stuart; Kraft, Colleen S.; Wolf, Timo

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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

Sep 01 2017
By Raabe, Vanessa N. ; Kann, Gerrit ; Ribner, Bruce S. ; ...
Source: Clin Infect Dis. 65(5):855-859.

[PDF-463.02 KB]

English

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Details:

Alternative Title:

Clin Infect Dis
Personal Author:

Raabe, Vanessa N. ; Kann, Gerrit ; Ribner, Bruce S. ; Morales, Andres ; Varkey, Jay B. ; ... More +

Raabe, Vanessa N. ; Kann, Gerrit ; Ribner, Bruce S. ; Morales, Andres ; Varkey, Jay B. ; Mehta, Aneesh K. ; Lyon, G. Marshall ; Vanairsdale, Sharon ; Faber, Kelly ; Becker, Stephan ; Eickmann, Markus ; Strecker, Thomas ; Brown, Shelley ; Patel, Ketan ; De Leuw, Philipp ; Schuettfort, Gundolf ; Stephan, Christoph ; Rabenau, Holger ; Klena, John D. ; Rollin, Pierre E. ; McElroy, Anita ; Ströher, Ute ; Nichol, Stuart ; Kraft, Colleen S. ; Wolf, Timo Less -
Corporate Authors:

for the Emory Serious Communicable Diseases Unit
Description:

Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.
Subjects:

[+]

Adult Amides/therapeutic Use Antiviral Agents/therapeutic Use Humans Lassa Fever Lassa Virus/genetics Male Polymerase Chain Reaction Pyrazines/therapeutic Use Ribavirin/therapeutic Use RNA, Viral
Source:

Clin Infect Dis. 65(5):855-859.
Pubmed ID:

29017278
Pubmed Central ID:

PMC5682919
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Place as Subject:

Togo
Volume:

65
Issue:

5
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:31bbea49a82c60c8500d2261581a6b9fe390f6d205cef359c4a81c8745bed7f7
Download URL:

https://stacks.cdc.gov/view/cdc/49791/cdc_49791_DS1.pdf
File Type:

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