Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; Cooper, Vaughn S. ; Tait-Kamradt, Amelia ; ... More +
Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; Cooper, Vaughn S. ; Tait-Kamradt, Amelia ; Wang, Minggui ; Hu, Fupin ; Rice, Louis B. ; Sluis-Cremer, Nicolas ; Doi, Yohei Less -
Description:
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
Subject:
[+]
Antimicrobial Resistance
Bacteria
Dispatch
Enterococcus Faecium
Fosfomycin
Fosfomycin Resistance
High-Level Fosfomycin Resistance In Vancomycin-Resistant Enterococcus Faecium
MurA
UDP-N-acetylglucosamine Enolpyruvyl Transferase
Vancomycin
Vancomycin-resistant Enterococci
Vancomycin Resistance

Source:
Emerg Infect Dis. 23(11):1902-1904.
Pubmed ID:
29048285
Pubmed Central ID:
PMC5652432
Document Type:
Journal Article
Funding:
R01 AI104895/AI/NIAID NIH HHS/United States ; R21 AI123747/AI/NIAID NIH HHS/United States
R01 AI104895/AI/NIAID NIH HHS/United States ; R21 AI123747/AI/NIAID NIH HHS/United States Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:4a9925afb8f346f813ccf87d3690b5aec8413b5fd75d0472a844cdbd790fc9f6
File Type:

Supporting Files

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  	17-1130-Techapp-s1.pdf	pdf
  	17-1130.nxml	xml

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