High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; Cooper, Vaughn S. ; Tait-Kamradt, Amelia ; Wang, Minggui ; Hu, Fupin ; Rice, Louis B. ; Sluis-Cremer, Nicolas ; Doi, Yohei
• Description:
  Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
• Subjects:
  Antimicrobial Resistance Bacteria Dispatch Enterococcus Faecium Fosfomycin Fosfomycin Resistance High-Level Fosfomycin Resistance In Vancomycin-Resistant Enterococcus Faecium MurA UDP-N-acetylglucosamine Enolpyruvyl Transferase Vancomycin Vancomycin-resistant Enterococci Vancomycin Resistance

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• Source:
  Emerg Infect Dis. 23(11):1902-1904.
• Pubmed ID:
  29048285
• Pubmed Central ID:
  PMC5652432
• Document Type:
  Journal Article
• Funding:
  R01 AI104895/AI/NIAID NIH HHS/United States ; R21 AI123747/AI/NIAID NIH HHS/United States
• Volume:
  23
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4a9925afb8f346f813ccf87d3690b5aec8413b5fd75d0472a844cdbd790fc9f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/49594/cdc_49594_DS1.pdf
• File Type:
  [PDF - 491.51 KB ]