High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium

Guo, Yan; Tomich, Adam D.; McElheny, Christi L.; Cooper, Vaughn S.; Tait-Kamradt, Amelia; Wang, Minggui; Hu, Fupin; Rice, Louis B.; Sluis-Cremer, Nicolas; Doi, Yohei

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High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium

Nov 2017
By Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; ...
Source: Emerg Infect Dis. 23(11):1902-1904.

[PDF-491.51 KB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; Cooper, Vaughn S. ; Tait-Kamradt, Amelia ; ... More +

Guo, Yan ; Tomich, Adam D. ; McElheny, Christi L. ; Cooper, Vaughn S. ; Tait-Kamradt, Amelia ; Wang, Minggui ; Hu, Fupin ; Rice, Louis B. ; Sluis-Cremer, Nicolas ; Doi, Yohei Less -
Description:

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
Subjects:

[+]

Antimicrobial Resistance Bacteria Dispatch Enterococcus Faecium Fosfomycin Fosfomycin Resistance High-Level Fosfomycin Resistance In Vancomycin-Resistant Enterococcus Faecium MurA UDP-N-acetylglucosamine Enolpyruvyl Transferase Vancomycin Vancomycin-resistant Enterococci Vancomycin Resistance
Source:

Emerg Infect Dis. 23(11):1902-1904.
Pubmed ID:

29048285
Pubmed Central ID:

PMC5652432
Document Type:

Journal Article
Funding:

R01 AI104895/AI/NIAID NIH HHS/United States ; R21 AI123747/AI/NIAID NIH HHS/United States

R01 AI104895/AI/NIAID NIH HHS/United States ; R21 AI123747/AI/NIAID NIH HHS/United States Less -
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:4a9925afb8f346f813ccf87d3690b5aec8413b5fd75d0472a844cdbd790fc9f6
Download URL:

https://stacks.cdc.gov/view/cdc/49594/cdc_49594_DS1.pdf
File Type:

	17-1130-F.gif	gif
	17-1130-F.jpg	jpeg
	17-1130-Techapp-s1.pdf	pdf
	17-1130.nxml	xml

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