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High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
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Published Date:
Nov 2017
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Source:Emerg Infect Dis. 23(11):1902-1904.
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Details:
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
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Subject:
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Pubmed ID:29048285
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Pubmed Central ID:PMC5652432
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