Effect of Cruciferous Vegetable Intake on Oxidative Stress Biomarkers: Differences by Breast Cancer Status

Details

• Alternative Title:
  Cancer Invest
• Personal Author:
  Wirth, Michael D. ; Murphy, E. Angela ; Hurley, Thomas G. ; Hébert, James R.
• Description:
  This post hoc analysis examined cruciferous vegetable intake on urinary oxidative metabolites in postmenopausal women. Intervention participants (n = 69) received cruciferous vegetables (≥14 cups/week) during a 3-week period. First morning urine measured 8-isoprostane and 8-hydroxy-2'-deoxyguanosine. Dietary intake was estimated using 24-h recalls. When stratified by history of breast cancer, those with breast cancer had significantly lower post-intervention urinary 8-hydroxy-2'-deoxyguanosine values in the intervention arm versus. the control arm (1.1 ng/mL vs. 3.2 ng/mL, p = .01) after adjustment for baseline 8-hydroxy-2'-deoxyguanosine. This was not observed in those without breast cancer. Further work is needed to understand the role of breast cancer in these relationships.
• Subjects:
  • Biomarkers, Tumor
  • Brassica
  • Breast Neoplasms
  • Case-Control Studies
  • Deoxyguanosine
  • Diet
  • Dinoprost
  • Female
  • Humans
  • Middle Aged
  More +
• Source:
  Cancer Invest. 35(4):277-287.
• Pubmed ID:
  28272911
• Pubmed Central ID:
  PMC5664216
• Document Type:
  Journal Article
• Funding:
  K05 CA136975/CA/NCI NIH HHS/United States ; U48 DP001936/DP/NCCDPHP CDC HHS/United States
• Volume:
  35
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/49543/cdc_49543_DS1.pdf
• File Type:
  [PDF - 475.94 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:84dda213790e3f5c291ccbaa42fdfdcdb6cc1d1a9e5438b0b16ee48da4dce47c