Lifetime personal cigarette smoking and risk of young-onset breast cancer by subtype among non-Hispanic Black and White women in the Young Women’s Health History Study

Details

• Alternative Title:
  Breast Cancer Res Treat
• Personal Author:
  Ihenacho, Ugonna ; Hamilton, Ann S. ; Mack, Wendy J. ; Wu, Anna H. ; Unger, Jennifer B. ; Pathak, Dorothy R. ; Hirko, Kelly A. ; Houang, Richard T. ; Press, Michael F. ; Schwartz, Kendra L. ; Marcus, Lydia R. ; Velie, Ellen M.
• Description:
  Purpose
  
  To evaluate the association between lifetime personal cigarette smoking and young-onset breast cancer (YOBC; diagnosed <50 years of age) risk overall and by breast cancer (BC) subtype, and whether risk varies by race or socioeconomic position (SEP).
  
  Methods
  
  Data are from the Young Women’s Health History Study (YWHHS), a population-based case-control study of non-Hispanic Black (NHB) and White (NHW) women, ages 20–49 years (n=1,812 cases, n=1,381 controls) in the Los Angeles County and Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) registry areas, 2010–2015. Lifetime personal cigarette smoking characteristics and YOBC risk by subtype were examined using sample-weighted, multivariable-adjusted polytomous logistic regression.
  
  Results
  
  YOBC risk associated with ever versus never smoking differed by subtype (Pheterogeneity=0.01) with risk significantly increased for Luminal A (adjusted odds ratio [aOR] 1.34; 95% confidence interval [CI] 1.06–1.68) and HER2-type (aOR 1.97; 95% CI 1.23–3.16), and no association with Luminal B or Triple Negative subtypes. Additionally, ≥30 years since smoking initiation (versus never) was statistically significantly associated with an increased risk of Luminal A (aOR 1.55; 95% CI 1.07–2.26) and HER2-type YOBC (aOR 2.77; 95% CI 1.32–5.79), but not other subtypes. Also, among parous women, smoking initiated before first full-term pregnancy (versus never) was significantly associated with an increased risk of Luminal A YOBC (aOR 1.45; 95% CI 1.11–1.89). We observed little evidence for interactions by race and SEP.
  
  Conclusion
  
  Findings confirm prior reports of a positive association between cigarette smoking and Luminal A YOBC and identify a novel association between smoking and HER2-type YOBC.
  
  
• Keywords:
  Adult Breast Neoplasms Case-Control Studies Cigarette Smoking Female Health Status Disparities Humans Middle Aged Molecular Subtype Pre-menopause Pregnancy Receptor, ErbB-2 Receptors, Estrogen Receptors, Progesterone Risk Factors Young-onset Breast Cancer Young Adult

  More +
• Source:
  Breast Cancer Res Treat. 195(3):353-366
• Pubmed ID:
  35925453
• Pubmed Central ID:
  PMC10424682
• Document Type:
  Journal Article
• Funding:
  HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA136861/CA/NCI NIH HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ ; R01CA136861/CA/NCI NIH HHSUnited States/
• Volume:
  195
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a913da7c9e11c376d7cfd793f5c9eb6d733f994448f9075610e348424ea1771e
• Download URL:
  https://stacks.cdc.gov/view/cdc/132031/cdc_132031_DS1.pdf
• File Type:
  [PDF - 217.38 KB ]