Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Achar, Jay ; Hewison, Cathy ; Cavalheiro, Ana P. ; Skrahina, Alena ; Cajazeiro, Junia ; Nargiza, Parpieva ; Herboczek, Krzysztof ; Rajabov, Assliddin S. ; Hughes, Jennifer ; Ferlazzo, Gabriella ; Seddon, James A. ; du Cros, Philipp
• Description:
  We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.
• Subjects:
  Adolescents Antimicrobial Resistance Bacteria Bedaquiline Children Dispatch MDR TB Multidrug-resistant Tuberculosis Multidrug Resistance Mycobacterium Tuberculosis Off-label Use Pediatric Respiratory Infections Treatment Tuberculosis XDR TB

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• Source:
  Emerg Infect Dis. 23(10):1711-1713.
• Pubmed ID:
  28758889
• Pubmed Central ID:
  PMC5621552
• Document Type:
  Journal Article
• Place as Subject:
  United Kingdom ; France ; Tajikistan ; Belarus ; Uzbekistan ; South Africa
• Location:
  Europe ; Asia ; Africa
• Volume:
  23
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:301a76b26a3e6564c329d3e918d9c2bb9e6abbed78597649108805b58db745ce
• Download URL:
  https://stacks.cdc.gov/view/cdc/48982/cdc_48982_DS1.pdf
• File Type:
  [PDF - 346.30 KB ]