Details:

Alternative Title:
Angew Chem Int Ed Engl
Personal Author:
Boehle, Katherine E. ; Gilliand, Jake ; Wheeldon, Christopher R. ; Holder, Amethyst ; Adkins, Jaclyn A. ; ... More +
Boehle, Katherine E. ; Gilliand, Jake ; Wheeldon, Christopher R. ; Holder, Amethyst ; Adkins, Jaclyn A. ; Geiss, Brian J. ; Ryan, Elizabeth P. ; Henry, Charles S. Less -
Description:
Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper-based analytical devices (PADs) that can test for the presence of β-lactamase-mediated resistance. To demonstrate viability, the PAD was used to detect β-lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources.
Subject:
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Antimicrobial Resistance
Article
Nitrocefin
Paper-based Analytical Devices
β-lactam Antibiotics
β-lactamase

Source:
Angew Chem Int Ed Engl. 56(24):6886-6890.
Pubmed ID:
28474847
Pubmed Central ID:
PMC5568866
Document Type:
Journal Article
Funding:
R01 OH010662/OH/NIOSH CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8f77d56775dd5de79d34f31851786437155f1e1c8dc51195e51912f699d8f55a
File Type:

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