Utilizing Paper-Based Devices for Antimicrobial-Resistant Bacteria Detection

Details

• Personal Author:
  Adkins JA ; Boehle KE ; Geiss BJ ; Gilliand J ; Henry CS ; Holder A ; Ryan EP ; Wheeldon CR
• Description:
  Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper-based analytical devices (PADs) that can test for the presence of beta-lactamase-mediated resistance. To demonstrate viability, the PAD was used to detect beta-lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources. [Description provided by NIOSH]
• Subjects:
  Anti-Bacterial Agents Biopharmaceutics Chemistry Chemistry, Analytic Communicable Diseases Environmental Monitoring Environmental Pollution Enzymes Mortality Occupational Health Safety

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• Keywords:
  Analytical-chemistry Analytical-instruments Antibiotics Antimicrobial Resistance Antimicrobials Author Keywords: Antimicrobial Resistance Bacteria Bacterial Disease Bacterial Infections Beta-lactam Antibiotics Beta-lactamase Carbon Carbonyls Chemical-analysis Costs Detectors Disease Transmission Drugs Environmental Contamination Environmental Monitoring Enzymatic-effects Infection Control Infection Prevention Infectious Agents Mortality Data Nitrocefin Nitro Compounds Nitrogen Paper-based Analytical Devices Pharmaceuticals Pharmacodynamics Testing Equipment Water Analysis Water Supply

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• ISSN:
  1433-7851
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  56
• Issue:
  24
• NIOSHTIC Number:
  nn:20050999
• Citation:
  Angew Chem Int Ed Engl 2017 Jun; 56(24):6886-6890
• Contact Point Address:
  Dr. C. S. Henry, Department of Chemistry, Colorado State University Fort Collins, CO 80523, USA
• Email:
  Chuck.Henry@colostate.edu
• CAS Registry Number:
  Nitrocefin (CAS RN 41906-86-9)
• Federal Fiscal Year:
  2017
• Performing Organization:
  Colorado State University, Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Angewandte Chemie (International Edition) English
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4253f70d150c70e821676b27acc8762efec87b6ff4fbe8d5282eb490ab92809227ee8837802077a42b803b931b2e86f46fb98a158460f2b334f35eda00f5acdf
• Download URL:
  https://stacks.cdc.gov/view/cdc/211144/cdc_211144_DS1.pdf
• File Type:
  [PDF - 2.83 MB ]