Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use

Details

• Alternative Title:
  Contraception
• Personal Author:
  Haaland, Richard E. ; Holder, Angela ; Evans-Strickfaden, Tammy ; Nyagol, Beatrice ; Makanga, Mumbi ; Oyaro, Boaz ; Humwa, Felix ; Williams, Tiffany ; McLellan-Lemal, Eleanor ; Desai, Mitesh ; Huey, Michael J.
  More +
• Description:
  Objective ; This study sought to measure residual contraceptive hormone levels in vaginal rings as an adherence marker for monitoring product use in clinical trials. ; Study design ; Residual etonogestrel and ethinyl estradiol levels from used NuvaRings® of 26 self-reported adherent women enrolled in a clinical trial of vaginal ring acceptability were compared to those from 16 women who used NuvaRing® as their contraceptive choice. ; Results ; Twenty-one (81%) clinical trial rings had contraceptive hormone levels within the range of those used as a contraceptive choice. Five returned rings had unused or discordant levels of residual contraceptive hormones. ; Conclusion ; Residual vaginal ring drug levels could help assess adherence in clinical trials.
• Subjects:
  • Administration, Intravaginal
  • Clinical Trials as Topic
  • Contraceptive Agents, Female
  • Contraceptive Devices, Female
  • Desogestrel
  • Drug Combinations
  • Ethinyl Estradiol
  • Female
  • Humans
  • Patient Compliance
• Source:
  Contraception. 95(6):602-604.
• Pubmed ID:
  28372978
• Pubmed Central ID:
  PMC5551387
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Kenya ; United States
• Volume:
  95
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/47482/cdc_47482_DS1.pdf
• File Type:
  [PDF - 255.02 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:dbdb28797c928a584c423bd1070dddf349bdb10d6ba4c06e64b20651d4b3dd77