Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use

Haaland, Richard E.; Holder, Angela; Evans-Strickfaden, Tammy; Nyagol, Beatrice; Makanga, Mumbi; Oyaro, Boaz; Humwa, Felix; Williams, Tiffany; McLellan-Lemal, Eleanor; Desai, Mitesh; Huey, Michael J.

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Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use

Apr 01 2017
By Haaland, Richard E. ; Holder, Angela ; Evans-Strickfaden, Tammy ; ...
Source: Contraception. 95(6):602-604.

[PDF-255.02 KB]

English

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Details:

Alternative Title:

Contraception
Personal Author:

Haaland, Richard E. ; Holder, Angela ; Evans-Strickfaden, Tammy ; Nyagol, Beatrice ; Makanga, Mumbi ; ... More +

Haaland, Richard E. ; Holder, Angela ; Evans-Strickfaden, Tammy ; Nyagol, Beatrice ; Makanga, Mumbi ; Oyaro, Boaz ; Humwa, Felix ; Williams, Tiffany ; McLellan-Lemal, Eleanor ; Desai, Mitesh ; Huey, Michael J. Less -
Description:

Objective

This study sought to measure residual contraceptive hormone levels in vaginal rings as an adherence marker for monitoring product use in clinical trials.

Study design

Residual etonogestrel and ethinyl estradiol levels from used NuvaRings® of 26 self-reported adherent women enrolled in a clinical trial of vaginal ring acceptability were compared to those from 16 women who used NuvaRing® as their contraceptive choice.

Results

Twenty-one (81%) clinical trial rings had contraceptive hormone levels within the range of those used as a contraceptive choice. Five returned rings had unused or discordant levels of residual contraceptive hormones.

Conclusion

Residual vaginal ring drug levels could help assess adherence in clinical trials.
Subjects:

[+]

Administration, Intravaginal Clinical Trials As Topic Contraceptive Agents, Female Contraceptive Devices, Female Desogestrel Drug Combinations Ethinyl Estradiol Female Humans Patient Compliance
Source:

Contraception. 95(6):602-604.
Pubmed ID:

28372978
Pubmed Central ID:

PMC5551387
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Place as Subject:

Kenya ; United States

Kenya ; United States Less -
Volume:

95
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:dbdb28797c928a584c423bd1070dddf349bdb10d6ba4c06e64b20651d4b3dd77
Download URL:

https://stacks.cdc.gov/view/cdc/47482/cdc_47482_DS1.pdf
File Type:

	NIHMS889056-supplement-Supplementary_Methods.docx	docx
	nihms889056.nxml	xml
	nihms889056f1.gif	gif
	nihms889056f1.jpg	jpeg

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