Repeated Administration of High Dose Depot Medroxy Progesterone Acetate does not Alter SHIVSF162p3 Viral Kinetics and Tenofovir Pharmacokinetics when Delivered via Intravaginal Rings

Details

• Alternative Title:
  J Med Primatol
• Personal Author:
  Srinivasan, Priya ; Zhang, Jining ; Dinh, Chuong T. ; Teller, Ryan S. ; McNicholl, Janet M. ; Kiser, Patrick F. ; Herold, Betsy C. ; Smith, James M.
• Description:
  Background
  
  Intravaginal rings (IVR) for HIV prevention will likely be used by women on depot medroxy progesterone acetate (DMPA) hormonal contraception. We used pigtailed macaques to evaluate the effects of DMPA on tenofovir disoproxil fumarate (TDF) IVR pharmacokinetics and viral shedding.
  
  Methods
  
  Mucosal tenofovir (TFV) levels were compared in SHIVSF162p3-negative DMPA-treated (n=4) and normally cycling (n=4) macaques receiving TDF IVRs. Plasma viremia and vaginal shedding were determined in groups of SHIVSF162p3-positive DMPA-treated (n=6) and normally cycling (n=5) macaques.
  
  Results
  
  Similar median vaginal fluid TFV concentrations were observed in the DMPA-treated and cycling macaques over 4 weeks (1.2 x 105 and 1.1. x 105 ng/mL respectively). Median plasma viremia and vaginal shedding AUC of the DMPA-treated (2.73 x 107 and 8.15 x 104 copies/mL respectively) and cycling macaques (3.98 x 107 and 1.47 x 103 copies/mL respectively) were statistically similar.
  
  Conclusions
  
  DMPA does not affect TDF IVR pharmacokinetics or SHIV shedding.
  
  
• Subjects:
  Administration, Intravaginal Animals Anti-HIV Agents Contraceptive Agents, Female Contraceptive Devices, Female Female HIV HIV Infections Macaca Nemestrina Medroxyprogesterone Acetate Tenofovir Viremia Virus Shedding

  More +
• Keywords:
  DMPA And HIV Mucosal HIV Shedding Nonhuman Primates SHIV Tenofovir Pharmacokinetics
• Source:
  J Med Primatol. 46(4):129-136
• Pubmed ID:
  28748662
• Pubmed Central ID:
  PMC7192064
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U19 AI103461/AI/NIAID NIH HHSUnited States/
• Volume:
  46
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:95c3775ae79c32a535282a6b0d62488338ae6891c1f529f5ce791e2553bf53b81ab1b899f7fb93018774a419e7af9eecde7715a6e2b6e7c3eaf78e137fae6446
• Download URL:
  https://stacks.cdc.gov/view/cdc/87457/cdc_87457_DS1.pdf
• File Type:
  [PDF - 510.23 KB ]