Repeated Administration of High Dose Depot Medroxy Progesterone Acetate does not Alter SHIVSF162p3 Viral Kinetics and Tenofovir Pharmacokinetics when Delivered via Intravaginal Rings

Srinivasan, Priya; Zhang, Jining; Dinh, Chuong T.; Teller, Ryan S.; McNicholl, Janet M.; Kiser, Patrick F.; Herold, Betsy C.; Smith, James M.

doi:10.1111/jmp.12299

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Repeated Administration of High Dose Depot Medroxy Progesterone Acetate does not Alter SHIVSF162p3 Viral Kinetics and Tenofovir Pharmacokinetics when Delivered via Intravaginal Rings

8 2017
By Srinivasan, Priya ; Zhang, Jining ; Dinh, Chuong T. ; ...
http://dx.doi.org/10.1111/jmp.12299
Source: J Med Primatol. 46(4):129-136

[PDF-510.23 KB]

English

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Details:

Alternative Title:

J Med Primatol
Personal Author:

Srinivasan, Priya ; Zhang, Jining ; Dinh, Chuong T. ; Teller, Ryan S. ; McNicholl, Janet M. ; ... More +

Srinivasan, Priya ; Zhang, Jining ; Dinh, Chuong T. ; Teller, Ryan S. ; McNicholl, Janet M. ; Kiser, Patrick F. ; Herold, Betsy C. ; Smith, James M. Less -
Description:

Background

Intravaginal rings (IVR) for HIV prevention will likely be used by women on depot medroxy progesterone acetate (DMPA) hormonal contraception. We used pigtailed macaques to evaluate the effects of DMPA on tenofovir disoproxil fumarate (TDF) IVR pharmacokinetics and viral shedding.

Methods

Mucosal tenofovir (TFV) levels were compared in SHIVSF162p3-negative DMPA-treated (n=4) and normally cycling (n=4) macaques receiving TDF IVRs. Plasma viremia and vaginal shedding were determined in groups of SHIVSF162p3-positive DMPA-treated (n=6) and normally cycling (n=5) macaques.

Results

Similar median vaginal fluid TFV concentrations were observed in the DMPA-treated and cycling macaques over 4 weeks (1.2 x 105 and 1.1. x 105 ng/mL respectively). Median plasma viremia and vaginal shedding AUC of the DMPA-treated (2.73 x 107 and 8.15 x 104 copies/mL respectively) and cycling macaques (3.98 x 107 and 1.47 x 103 copies/mL respectively) were statistically similar.

Conclusions

DMPA does not affect TDF IVR pharmacokinetics or SHIV shedding.
Subjects:

[+]

Administration, Intravaginal Animals Anti-HIV Agents Contraceptive Agents, Female Contraceptive Devices, Female Female HIV HIV Infections Macaca Nemestrina Medroxyprogesterone Acetate Tenofovir Viremia Virus Shedding
Keywords:

[+]

DMPA And HIV Mucosal HIV Shedding Nonhuman Primates SHIV Tenofovir Pharmacokinetics
Source:

J Med Primatol. 46(4):129-136
Pubmed ID:

28748662
Pubmed Central ID:

PMC7192064
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U19 AI103461/AI/NIAID NIH HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U19 AI103461/AI/NIAID NIH HHSUnited States/ Less -
Volume:

46
Issue:

4
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:95c3775ae79c32a535282a6b0d62488338ae6891c1f529f5ce791e2553bf53b81ab1b899f7fb93018774a419e7af9eecde7715a6e2b6e7c3eaf78e137fae6446
Download URL:

https://stacks.cdc.gov/view/cdc/87457/cdc_87457_DS1.pdf
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